Type

Journal Article

Authors

Joanne Lysaght
Jacintha O'Sullivan
John V Reynolds
Narayanasamy Ravi
Dermot O'Toole
Finbar MacCarthy
Ronan Feighery
Katie E O'Sullivan
Niamh T Gilmartin
Niamh E Clarke
and 2 others

Subjects

Biochemistry

Topics
il 10 il 6 t cell anti inflammatory cd4 t cells disease progression oesophageal adenocarcinoma inflammatory cytokines

Impact of the inflammatory microenvironment on T-cell phenotype in the progression from reflux oesophagitis to Barrett oesophagus and oesophageal adenocarcinoma. (2015)

Abstract The incidence of oesophageal adenocarcinoma (OAC), arising from reflux-induced Barrett oesophagus (BO), is increasing dramatically. T-cells have recently been implicated in the initiation of oesophagitis; however, their role in the progression from oesophagitis to BO and OAC has not been fully elucidated. Previous studies have examined the secreted cytokines from oesophageal tissue during disease progression but this study is the first to examine the activation phenotype and the inflammatory profile of CD4(+) and CD8(+) T-cells in human oesophagitis, BO and OAC tissue. Results demonstrated significantly higher levels of IL-4 producing CD4(+) T-cells and secreted levels of IL-6, confirming a Th2 phenotype in BO. In OAC tissue, both pro- and anti-inflammatory cytokines were secreted, with significantly higher levels of IL-6, IL-1β, TNF-α, IFN-γ, IL-2 and IL-10 compared with normal oesophageal tissue. In addition, CD4(+) T-cells infiltrating OAC tissue displayed a decreased activation profile, with significantly lower CD45RO and CD69 expression compared with normal tissue. Data from this study suggest that factors in the tissue microenvironment may alter T-cell phenotype and function early during oesophageal disease progression and may represent targets for immune intervention.
Collections Ireland -> Trinity College Dublin -> PubMed

Full list of authors on original publication

Joanne Lysaght, Jacintha O'Sullivan, John V Reynolds, Narayanasamy Ravi, Dermot O'Toole, Finbar MacCarthy, Ronan Feighery, Katie E O'Sullivan, Niamh T Gilmartin, Niamh E Clarke and 2 others

Experts in our system

1
Joanne Lysaght
Trinity College Dublin
Total Publications: 39
 
2
Jacintha O'Sullivan
Trinity College Dublin
Total Publications: 74
 
3
J V Reynolds
Trinity College Dublin
Total Publications: 206
 
4
N Ravi
Trinity College Dublin
Total Publications: 61
 
5
F MacCarthy
Trinity College Dublin
Total Publications: 4
 
6
Ronan Feighery
Trinity College Dublin
Total Publications: 10
 
7
Katie E O'Sullivan
Trinity College Dublin
 
8
Niamh Gilmartin
TU Dublin
Total Publications: 6