Type

Journal Article

Authors

Peter J Kelly
Lorraine Kyne
David Williams
Eamon Dolan
Killian O'Rourke
Sean Murphy
Joseph Duggan
Gillian Horgan
Derek Hayden
Aine Merwick
and 6 others

Subjects

Medicine & Nursing

Topics
population prospective methodology recurrence stroke secondary prevention year 1 north dublin outcomes

Rates, Predictors, and Outcomes of Early and Late Recurrence After Stroke: The North Dublin Population Stroke Study. (2015)

Abstract Few recent studies have investigated the rates and predictors of early and late stroke recurrence using prospective population-based methodology. We investigated recurrent stroke at 2 years in the North Dublin Population Stroke Study (NDPSS). Patients were ascertained from December 2005 to 2006 from overlapping community and hospital sources using hot and cold pursuit. Stroke recurrence, survival, and functional outcome were ascertained at 72 hours, 7 days, 28 days, 90 days, 1 year, and 2 years. Of 567 patients, cumulative 2-year stroke recurrence rate was 10.8% and case fatality was 38.6%. Recurrence subtype was associated with initial stroke subtype (P<0.001). On multivariable Cox regression, hyperlipidemia (adjusted hazard ratio, 3.32; P=0.005) and prior stroke (adjusted hazard ratio, 2.92; P=0.01) were independent predictors of 2-year recurrence in 28-day survivors. Despite rigorous ascertainment, recurrent stroke rates were lower in current study than in earlier studies. Our data suggest that large sample sizes may be needed for future secondary prevention trials in patients treated with modern preventive medications.
Collections Ireland -> University College Dublin -> PubMed

Full list of authors on original publication

Peter J Kelly, Lorraine Kyne, David Williams, Eamon Dolan, Killian O'Rourke, Sean Murphy, Joseph Duggan, Gillian Horgan, Derek Hayden, Aine Merwick and 6 others

Experts in our system

1
Peter J Kelly
University College Dublin
Total Publications: 35
 
2
Lorraine Kyne
University College Dublin
Total Publications: 25
 
3
David Williams
Royal College of Surgeons in Ireland
Total Publications: 82
 
4
Eamon Dolan
IT Blanchardstown
Total Publications: 42
 
5
Killian O'Rourke
University College Dublin
Total Publications: 5
 
6
Sean Murphy
University College Dublin
Total Publications: 35
 
7
Joseph Duggan
University College Dublin
Total Publications: 11
 
8
Gillian Horgan
University College Dublin
Total Publications: 11
 
9
Derek Hayden
IT Blanchardstown
Total Publications: 4
 
10
Aine Merwick
University College Dublin
Total Publications: 11