Type

Journal Article

Authors

Ken O'Byrne
S Heavey
Kathy Gately
A M Baird
Martin Barr
P Godwin

Subjects

Medicine & Nursing

Topics
cancer patients factor kappa b resistance cisplatin chemotherapy apoptosis nf b chemotherapeutic agents dna repair biomedical sciences transcription factor cancer multi drug resistance oncogene anti cancer

Targeting nuclear factor-kappa B to overcome resistance to chemotherapy. (2013)

Abstract Intrinsic or acquired resistance to chemotherapeutic agents is a common phenomenon and a major challenge in the treatment of cancer patients. Chemoresistance is defined by a complex network of factors including multi-drug resistance proteins, reduced cellular uptake of the drug, enhanced DNA repair, intracellular drug inactivation, and evasion of apoptosis. Pre-clinical models have demonstrated that many chemotherapy drugs, such as platinum-based agents, antracyclines, and taxanes, promote the activation of the NF-κB pathway. NF-κB is a key transcription factor, playing a role in the development and progression of cancer and chemoresistance through the activation of a multitude of mediators including anti-apoptotic genes. Consequently, NF-κB has emerged as a promising anti-cancer target. Here, we describe the role of NF-κB in cancer and in the development of resistance, particularly cisplatin. Additionally, the potential benefits and disadvantages of targeting NF-κB signaling by pharmacological intervention will be addressed.
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Full list of authors on original publication

Ken O'Byrne, S Heavey, Kathy Gately, A M Baird, Martin Barr, P Godwin

Experts in our system

1
Ken O'Byrne
Trinity College Dublin
Total Publications: 49
 
2
Susan Heavey
Trinity College Dublin
Total Publications: 7
 
3
Kathy Gately
Trinity College Dublin
Total Publications: 22
 
4
Anne-Marie Baird
Trinity College Dublin
Total Publications: 17
 
5
Martin P Barr
Trinity College Dublin
Total Publications: 27