Type

Other / n/a

Authors

Emer P Reeves
Noel G McElvaney
Killian Hurley
Niall Browne
Fatma Gargoum
Michelle M White

Subjects

Medicine & Nursing

Topics
cystic fibrosis transmembrane conductance regulator bacterial infections cystic fibrosis medicine and health sciences neutrophil function importance research activity inflammation

New Research on the Importance of Cystic Fibrosis Transmembrane Conductance Regulator Function for Optimal Neutrophil Activity (2015)

Abstract Despite tremendous recent advances in our understanding of the molecular and cellular basis of cystic fibrosis (CF), there remains a paradox of why recruited neutrophils fail to eradicate bacterial infections in the airways of individuals with CF. The focus of this chapter is on new research authenticating the CF neutrophil as a key player in disease pathogenesis. Studies specifying intrinsic abnormalities due to a lack of cystic fibrosis transmembrane conductance regulator (CFTR) function, along with reports indicating reprogrammed cell activity secondary to chronic bacterial infection and inflammation, will be discussed.
Collections Ireland -> Royal College of Surgeons in Ireland -> Medicine Articles
Ireland -> Royal College of Surgeons in Ireland -> Department of Medicine

Full list of authors on original publication

Emer P Reeves, Noel G McElvaney, Killian Hurley, Niall Browne, Fatma Gargoum, Michelle M White

Experts in our system

1
Emer P Reeves
Royal College of Surgeons in Ireland
Total Publications: 63
 
2
Noel G McElvaney
Royal College of Surgeons in Ireland
Total Publications: 194
 
3
Fatma S Gargoum
Royal College of Surgeons in Ireland
 
4
Michelle M White
Royal College of Surgeons in Ireland
Total Publications: 10