Type

Other / n/a

Authors

Noel G McElvaney
Catherine M Greene
Emer Kelly

Subjects

Medicine & Nursing

Topics
neutrophil elastase this review leukocyte elastase extracellular matrix proteins medicine and health sciences humans enzyme inhibitors cystic fibrosis

Targeting neutrophil elastase in cystic fibrosis. (2008)

Abstract BACKGROUND: Cystic fibrosis (CF) is a lethal hereditary disease characterised by neutrophil-dominated lung inflammation. These abundant neutrophils produce neutrophil elastase (NE), a destructive serine protease that has direct actions on extracellular matrix proteins and has a role in the host response to inflammation and infection.OBJECTIVE: This review examines the prospect of developing novel therapies for CF by targeting NE. The authors explore the functions of NE and of naturally-occurring and synthetic NE inhibitors.METHODS: A literature search was conducted exploring the functions of NE and inhibitors of NE; naturally occurring and synthetic.CONCLUSIONS: Targeting NE in CF offers therapeutic potential, but optimal inhibitors that can be delivered safely and effectively to the lung are still under development.
Collections Ireland -> Royal College of Surgeons in Ireland -> Medicine Articles
Ireland -> Royal College of Surgeons in Ireland -> Department of Medicine

Full list of authors on original publication

Noel G McElvaney, Catherine M Greene, Emer Kelly

Experts in our system

1
Noel G McElvaney
Royal College of Surgeons in Ireland
Total Publications: 194
 
2
Catherine M Greene
Royal College of Surgeons in Ireland
Total Publications: 150