Type

Other / n/a

Authors

Joseph Keane
Mary P O'Sullivan
Sally-Ann Cryan
Aidan Fagan-Murphy
Laura E Gleeson
Gemma O'Connor

Subjects

Pharmacology

Topics
vitamin inhalation pre clinical testing immunomodulation targeted drug delivery ant tubercular particle engineering adjunctive therapy pharmacy and pharmaceutical sciences

Sharpening nature's tools for efficient tuberculosis control: A review of the potential role and development of host-directed therapies and strategies for targeted respiratory delivery. (2016)

Abstract Centuries since it was first described, tuberculosis (TB) remains a significant global public health issue. Despite ongoing holistic measures implemented by health authorities and a number of new oral treatments reaching the market, there is still a need for an advanced, efficient TB treatment. An adjunctive, host-directed therapy designed to enhance endogenous pathways and hence compliment current regimens could be the answer. The integration of drug repurposing, including synthetic and naturally occurring compounds, with a targeted drug delivery platform is an attractive development option. In order for a new anti-tubercular treatment to be produced in a timely manner, a multidisciplinary approach should be taken from the outset including stakeholders from academia, the pharmaceutical industry, and regulatory bodies keeping the patient as the key focus. Pre-clinical considerations for the development of a targeted host-directed therapy are discussed here.
Collections Ireland -> Royal College of Surgeons in Ireland -> School of Pharmacy
Ireland -> Royal College of Surgeons in Ireland -> School of Pharmacy Articles

Full list of authors on original publication

Joseph Keane, Mary P O'Sullivan, Sally-Ann Cryan, Aidan Fagan-Murphy, Laura E Gleeson, Gemma O'Connor

Experts in our system

1
Joseph Keane
Trinity College Dublin
Total Publications: 54
 
2
Mary P O'Sullivan
Trinity College Dublin
Total Publications: 19
 
3
Sally-Ann Cryan
Royal College of Surgeons in Ireland
Total Publications: 70
 
4
Gemma O'Connor
Royal College of Surgeons in Ireland
Total Publications: 5