Type

Journal Article

Authors

P.M Jakeman
Peter M. Anderson
Barbara Tomik
Agnieska Slowik
Jean Saunders
Russell Mclaughlin
Simon Cronin
Orla Hardiman
Matthew Greenway
David S. Lynch
and 4 others

Subjects

Psychiatry

Topics
angiogenin snp genotypes cerebrospinal fluid ang gene allelic association statistics ireland polymorphism single nucleotide humans international integration linkage disequilibrium genotype gene frequency single nucleotide polymorphisms alleles genetics amyotrophic lateral sclerosis genetic predisposition to disease sweden genotypes ribonuclease pancreatic poland haplotypes blood

Angiogenin Levels and ANG Genotypes: Dysregulation in Amyotrophic Lateral Sclerosis (2010)

Abstract Objective: To determine whether 5 single nucleotide polymorphisms (SNPs) associate with ALS in 3 different populations. We also assessed the contribution of genotype to angiogenin levels in plasma and CSF. Methods: Allelic association statistics were calculated for polymorphisms in the ANG gene in 859 patients and 1047 controls from Sweden, Ireland and Poland. Plasma, serum and CSF angiogenin levels were quantified and stratified according to genotypes across the ANG gene. The contribution of SNP genotypes to variance in circulating angiogenin levels was estimated in patients and controls. Results: All SNPs showed association with ALS in the Irish group. The SNP rs17114699 replicated in the Swedish cohort. No SNP associated in the Polish cohort. Age- and sex-corrected circulating angiogenin levels were significantly lower in patients than in controls (p<0.001). An allele dose-dependent regulation of angiogenin levels was observed in controls. This regulation was attenuated in the ALS cohort. A significant positive correlation between CSF plasma angiogenin levels was present in controls and abolished in ALS. Conclusions: ANG variants associate with ALS in the Irish and Swedish populations, but not in the Polish. There is evidence of dysregulation of angiogenin expression in plasma and CSF in sporadic ALS. Angiogenin expression is likely to be important in the pathogenesis of ALS.
Collections Ireland -> Trinity College Dublin -> RSS Feeds
Ireland -> University of Limerick -> Faculty of Education & Health Sciences
Ireland -> University of Limerick -> Departments Education & Health Sciences
Ireland -> Trinity College Dublin -> School of Genetics & Microbiology
Ireland -> Trinity College Dublin -> Genetics (Scholarly Publications)
Ireland -> Trinity College Dublin -> Genetics
Ireland -> Trinity College Dublin -> RSS Feeds
Ireland -> University of Limerick -> Physical Education and Sports Science

Full list of authors on original publication

P.M Jakeman, Peter M. Anderson, Barbara Tomik, Agnieska Slowik, Jean Saunders, Russell Mclaughlin, Simon Cronin, Orla Hardiman, Matthew Greenway, David S. Lynch and 4 others

Experts in our system

1
Philip M Jakeman
University of Limerick
Total Publications: 63
 
2
Jean Saunders
University of Limerick
Total Publications: 63
 
3
Russell L McLaughlin
Trinity College Dublin
Total Publications: 41
 
4
Simon Cronin
University College Cork
Total Publications: 15
 
5
Orla Hardiman
Trinity College Dublin
Total Publications: 156
 
6
David S Lynch
University College Dublin
Total Publications: 8