Journal Article


Paul McLoughlin
Seán Gaine
M. P. Keane
Simon C. Rowan



life expectancy signalling pathways lung diseases muscle tone chronic vasoconstriction pulmonary circulation pulmonary hypertension

Hypoxic pulmonary hypertension in chronic lung diseases: novel vasoconstrictor pathway (2016)

Abstract Pulmonary hypertension is a well recognised complication of chronic hypoxic lung diseases, which are among the most common causes of death and disability worldwide. Development of pulmonary hypertension independently predicts reduced life expectancy. In chronic obstructive pulmonary disease, long-term oxygen therapy ameliorates pulmonary hypertension and greatly improves survival, although the correction of alveolar hypoxia and pulmonary hypertension is only partial. Advances in understanding of the regulation of vascular smooth muscle tone show that chronic vasoconstriction plays a more important part in the pathogenesis of hypoxic pulmonary hypertension than previously thought, and that structural vascular changes contribute less. Trials of existing vasodilators show that pulmonary hypertension can be ameliorated and systemic oxygen delivery improved in carefully selected patients, although systemic hypotensive effects limit the doses used. Vasoconstrictor pathways that are selective for the pulmonary circulation can be blocked to reduce hypoxic pulmonary hypertension without causing systemic hypotension, and thus provide potential targets for novel therapeutic strategies.
Collections Ireland -> University College Dublin -> Conway Institute Research Collection
Ireland -> University College Dublin -> Conway Institute
Ireland -> University College Dublin -> Medicine Research Collection

Full list of authors on original publication

Paul McLoughlin, Seán Gaine, M. P. Keane, Simon C. Rowan

Experts in our system

Paul McLoughlin
University College Dublin
Sean Gaine
University College Dublin
Total Publications: 9
Michael P Keane
University College Dublin
Total Publications: 23
Simon C. Rowan
University College Dublin
Total Publications: 7