Journal Article


Michael D Gilchrist
Jeremiah G Murphy
Baptiste Pierrat
David B MacManus



medulla oblongata brain deformation cerebral cortex experimental data brain tissue traumatic brain injury finite element method dynamic mechanical properties

Mechanical characterization of the P56 mouse brain under large-deformation dynamic indentation. (2015)

Abstract The brain is a complex organ made up of many different functional and structural regions consisting of different types of cells such as neurons and glia, as well as complex anatomical geometries. It is hypothesized that the different regions of the brain exhibit significantly different mechanical properties, which may be attributed to the diversity of cells and anisotropy of neuronal fibers within individual brain regions. The regional dynamic mechanical properties of P56 mouse brain tissue in vitro and in situ at velocities of 0.71-4.28 mm/s, up to a deformation of 70 μm are presented and discussed in the context of traumatic brain injury. The experimental data obtained from micro-indentation measurements were fit to three hyperelastic material models using the inverse Finite Element method. The cerebral cortex elicited a stiffer response than the cerebellum, thalamus, and medulla oblongata regions for all velocities. The thalamus was found to be the least sensitive to changes in velocity, and the medulla oblongata was most compliant. The results show that different regions of the mouse brain possess significantly different mechanical properties, and a significant difference also exists between the in vitro and in situ brain.
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Full list of authors on original publication

Michael D Gilchrist, Jeremiah G Murphy, Baptiste Pierrat, David B MacManus

Experts in our system

M. D. Gilchrist
University College Dublin
Total Publications: 172
Jeremiah G Murphy
Dublin City University
Total Publications: 16
Baptiste Pierrat
Dublin City University
Total Publications: 8
David B MacManus
Dublin City University
Total Publications: 9