Type

Journal Article

Authors

Orla Hardiman
Anthony Staines
Russell McLaughlin
Katy Tobin
Arlene Crampsie
Mark Heverin
Alice Vajda
James Rooney

Subjects

Psychiatry

Topics
amyotrophic lateral sclerosis soil ireland risk factors deviance information criterion cluster analysis association spatial analysis

No association between soil constituents and amyotrophic lateral sclerosis relative risk in Ireland. (2015)

Abstract We have recently mapped ALS spatial risk in Ireland using Bayesian and cluster analysis methods at electoral division (ED) and small area (SA) levels. As a number of metal elements (both minerals and toxins) have been proposed as risk factors for ALS, here we extend this analysis to include soil constituents from the Irish National Soils Database as Bayesian conditional auto-regression covariates to determine associations with small area ALS risk. Data on 45 different soil parameters were obtained under license from National Soils Database (via Irish EPA). We interpolated average values of each soil constituent for each small area using ordinary kriging. All cases of ALS in Ireland from January 1995 to December 2013 were identified from the Irish ALS register and observed and age and gender standardised expected cases were calculated for each SA. Besag-York-MolliƩ (BYM) models were then built including each parameter from the national soils database in turn as a Bayesian covariate in the BYM model. Models were compared using the deviance information criterion (DIC) and separate models were built for ALS subtypes. 1701 ALS patients were included - 959 (56%) were male, 938 (55%) had limb onset ALS. 315 Bayesian models were built in total. Of the 315 models built, only one resulted in a coefficient that did not overlap zero. For limb onset cases, total magnesium had a mean coefficient of 0.319 (credible interval 0.033-0.607). We report the first spatial analysis of potential association between ALS and soil minerals using a population-based dataset collected over 18 years. Our sole non-zero finding is likely a random finding due to the high number of models built. We did not find any evidence to support soil mineral and toxin levels as risk factors for ALS. However as soil parameters are an ecological assessment of exposure in a given area, individual level measures of exposure are required.
Collections Ireland -> Dublin City University -> PubMed

Full list of authors on original publication

Orla Hardiman, Anthony Staines, Russell McLaughlin, Katy Tobin, Arlene Crampsie, Mark Heverin, Alice Vajda, James Rooney

Experts in our system

1
Orla Hardiman
Trinity College Dublin
Total Publications: 156
 
2
Anthony Staines
Dublin City University
Total Publications: 96
 
3
Russell L McLaughlin
Trinity College Dublin
Total Publications: 41
 
4
Katy Tobin
Dublin City University
Total Publications: 10
 
5
Mark Heverin
Trinity College Dublin
Total Publications: 21
 
6
Alice Vajda
Trinity College Dublin
Total Publications: 29
 
7
James Rooney
Trinity College Dublin
Total Publications: 23