Journal Article


Peter O'Gorman
Maria C Fitzgibbon
Martin Clynes
Paul Dowling
Paul G Richardson
Kenneth C Anderson
Dalia Benjamin
Christopher Bayers
Estelle Verburgh
Justine Meiller
and 4 others


Medicine & Nursing

collagen type 1 bone turnover patients multiple myeloma clinical utility treatment type 1 therapy

Clinical utility of C-terminal telopeptide of type 1 collagen in multiple myeloma. (2015)

Abstract Myeloma bone disease (MBD) is a major cause of morbidity in multiple myeloma (MM). We investigated bone turnover markers (BTM) as relapse predictors and biomarkers for monitoring MBD. We measured C-terminal telopeptide of type I collagen (CTX-1), and Procollagen type 1 N Propeptide (P1NP) in 86 MM patients and 26 controls. CTX-1 was higher in newly diagnosed patients compared to control, remission and relapse (P < 0·05), and decreased following treatment. In the setting of relapse, a CTX-1 rise greater than the calculated least significant change (LSC) was observed in 26% of patients 3-6 months prior to relapse (P = 0·007), and in 60·8% up to 3 months before relapse (P = 0·015). Statistically significant changes in CTX-1 levels were also observed in patients who were with and without bisphosphonate therapy at the time of relapse. In patients with normal renal function, mean CTX-1 level was highest in the newly diagnosed group (0·771 ± 0·400 μg/l), and lowest in the remission group (0·099 ± 0·070 μg/l) (P < 0·0001). P1NP levels were not statistically different across the patient groups. We conclude that CTX-1, measured on an automated hospital laboratory platform, has a role in routine treatment monitoring and predicting relapse of MBD, even in patients on bisphosphonates.
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Full list of authors on original publication

Peter O'Gorman, Maria C Fitzgibbon, Martin Clynes, Paul Dowling, Paul G Richardson, Kenneth C Anderson, Dalia Benjamin, Christopher Bayers, Estelle Verburgh, Justine Meiller and 4 others

Experts in our system

Peter O'Gorman
Dublin City University
Total Publications: 15
Martin Clynes
Dublin City University
Total Publications: 209
Paul Dowling
Dublin City University
Total Publications: 79
Paul Richardson
Dublin City University
Total Publications: 6
Kenneth Anderson
Dublin City University
Total Publications: 5
Justine Meiller
Dublin City University
Total Publications: 7