Type

Journal Article

Authors

Joanne Lysaght
John V Reynolds
Gillian Y Moore
Aoife Cannon
Ann-Marie Mongan
Maria E Kavanagh
Suzanne L Doyle
Karen C Galvin
Melissa J Conroy

Subjects

Medicine & Nursing

Topics
inflammatory cytokines t cells liver disease systemic inflammation cancer cells cancer patients oesophageal adenocarcinoma liver cells

Parallel Profiles of Inflammatory and Effector Memory T Cells in Visceral Fat and Liver of Obesity-Associated Cancer Patients. (2016)

Abstract In the midst of a worsening obesity epidemic, the incidence of obesity-associated morbidities, including cancer, diabetes, cardiac and liver disease is increasing. Insights into mechanisms underlying pathological obesity-associated inflammation are lacking. Both the omentum, the principal component of visceral fat, and liver of obese individuals are sites of excessive inflammation, but to date the T cell profiles of both compartments have not been assessed or compared in a patient cohort with obesity-associated disease. We have previously identified that omentum is enriched with inflammatory cytokines, chemokines and T cells. Here, we compared the inflammatory profile of T cells in the omentum and liver of patients with the obesity-associated malignancy oesophageal adenocarcinoma (OAC). Furthermore, we assessed the secreted cytokine profile in OAC patient serum, omentum and liver to assess systemic and local inflammation. We observed parallel T cell cytokine profiles and phenotypes in the omentum and liver of OAC patients, in particular CD69(+) and inflammatory effector memory T cells. This study reflects similar processes of inflammation and T cell activation in the omentum and liver, and may suggest common targets to modulate pathological inflammation at these sites.
Collections Ireland -> Dublin Institute of Technology -> PubMed

Full list of authors on original publication

Joanne Lysaght, John V Reynolds, Gillian Y Moore, Aoife Cannon, Ann-Marie Mongan, Maria E Kavanagh, Suzanne L Doyle, Karen C Galvin, Melissa J Conroy

Experts in our system

1
Joanne Lysaght
Trinity College Dublin
Total Publications: 39
 
2
J V Reynolds
Trinity College Dublin
Total Publications: 206
 
3
Aoife Cannon
TU Dublin
 
4
Ann-Marie Mongan
Trinity College Dublin
Total Publications: 6
 
5
Suzanne L Doyle
Trinity College Dublin
Total Publications: 23
 
6
Melissa J Conroy
Trinity College Dublin
Total Publications: 14