Type

Journal Article

Authors

Joanne Lysaght
John V Reynolds
Narayanasamy Ravi
Cliona O'Farrelly
Niamh Gilmartin
Zivile Useckaite
Shauna Channon
Suzanne L Doyle
Vivienne Fitzgerald
Melissa J Conroy

Subjects

Biochemistry

Topics
oesophageal adenocarcinoma chemokine receptor anti inflammatory il 10 cell function cell death adipose tissue cell viability

The microenvironment of visceral adipose tissue and liver alter natural killer cell viability and function. (2015)

Abstract The role of NK cells in visceral adipose tissue (VAT) and liver inflammation in obesity is not fully understood. This study investigated the frequency, cytokine expression, chemokine receptor, and cytotoxicity receptor profile of NK cells in the blood, omentum, and liver of patients with the obesity-associated cancer, oesophageal adenocarcinoma (OAC). The effect of chronically inflamed tissue microenvironments on NK cell viability and function was also examined. We identified significantly lower NK cell frequencies in the liver of OAC patients compared with healthy controls and within the omentum and liver of OAC patients compared with blood, whereas IL-10-producing populations were significantly higher. Interestingly, our data suggest that reduced frequencies of NK cells in omentum and liver of OAC patients are not a result of impaired NK cell chemotaxis to these tissues. In fact, our functional data revealed that secreted factors from omentum and liver of OAC patients induce significant levels of NK cell death and lead to reduced percentages of TNF-α(+) and NKP46(+) NK cells and higher frequencies of IL-10-producing NK cells. Together, these data suggest that the omental and hepatic microenvironments of OAC patients alter the NK cell phenotype to a more anti-inflammatory homeostatic role.
Collections Ireland -> Dublin Institute of Technology -> PubMed

Full list of authors on original publication

Joanne Lysaght, John V Reynolds, Narayanasamy Ravi, Cliona O'Farrelly, Niamh Gilmartin, Zivile Useckaite, Shauna Channon, Suzanne L Doyle, Vivienne Fitzgerald, Melissa J Conroy

Experts in our system

1
Joanne Lysaght
Trinity College Dublin
Total Publications: 39
 
2
J V Reynolds
Trinity College Dublin
Total Publications: 206
 
3
N Ravi
Trinity College Dublin
Total Publications: 61
 
4
Cliona O'Farrelly
Trinity College Dublin
Total Publications: 147
 
5
Niamh Gilmartin
TU Dublin
Total Publications: 6
 
6
Zivile Useckaite
Royal College of Surgeons in Ireland
Total Publications: 4
 
7
Suzanne L Doyle
Trinity College Dublin
Total Publications: 23
 
8
Melissa J Conroy
Trinity College Dublin
Total Publications: 14