Journal Article


M A Bellgrove
M Gill
L Kent
D Morris
E Kenny
N R Wray
S Easteal
F Levy
H S Heussler
A Vance
and 8 others



next generation sequencing risk factor genome wide association studies brain derived neurotrophic factor bdnf brain derived neurotrophic factor attention deficit hyperactivity disorder attention deficit hyperactivity disorder adhd large scale

Rare DNA variants in the brain-derived neurotrophic factor gene increase risk for attention-deficit hyperactivity disorder: a next-generation sequencing study. (2015)

Abstract Attention-deficit hyperactivity disorder (ADHD) is a prevalent and highly heritable disorder of childhood with negative lifetime outcomes. Although candidate gene and genome-wide association studies have identified promising common variant signals, these explain only a fraction of the heritability of ADHD. The observation that rare structural variants confer substantial risk to psychiatric disorders suggests that rare variants might explain a portion of the missing heritability for ADHD. Here we believe we performed the first large-scale next-generation targeted sequencing study of ADHD in 152 child and adolescent cases and 188 controls across an a priori set of 117 genes. A multi-marker gene-level analysis of rare (<1% frequency) single-nucleotide variants (SNVs) revealed that the gene encoding brain-derived neurotrophic factor (BDNF) was associated with ADHD at Bonferroni corrected levels. Sanger sequencing confirmed the existence of all novel rare BDNF variants. Our results implicate BDNF as a genetic risk factor for ADHD, potentially by virtue of its critical role in neurodevelopment and synaptic plasticity.Molecular Psychiatry advance online publication, 26 July 2016; doi:10.1038/mp.2016.117.
Collections Ireland -> National University of Ireland Galway -> PubMed

Full list of authors on original publication

M A Bellgrove, M Gill, L Kent, D Morris, E Kenny, N R Wray, S Easteal, F Levy, H S Heussler, A Vance and 8 others

Experts in our system

Michael Gill
Trinity College Dublin
Total Publications: 294
Derek Morris
Trinity College Dublin
Total Publications: 168
Elaine Kenny
Trinity College Dublin
Total Publications: 32