Type

Journal Article

Authors

Kieran C Murphy
Hugh Garavan
Colm McDonald
Alexander Leemans
Jane McGrath
Sarah Prasad
Sarah Howley
Erik O'Hanlon

Subjects

Psychiatry

Topics
white matter voxel based morphometry structural connectivity 22q11 deletion syndrome mri magnetic resonance imaging spatial working memory corpus callosum

Multimodal MRI reveals structural connectivity differences in 22q11 deletion syndrome related to impaired spatial working memory. (2014)

Abstract Impaired spatial working memory is a core cognitive deficit observed in people with 22q11 Deletion syndrome (22q11DS) and has been suggested as a candidate endophenotype for schizophrenia. However, to date, the neuroanatomical mechanisms describing its structural and functional underpinnings in 22q11DS remain unclear. We quantitatively investigate the cognitive processes and associated neuroanatomy of spatial working memory in people with 22q11DS compared to matched controls. We examine whether there are significant between-group differences in spatial working memory using task related fMRI, Voxel based morphometry and white matter fiber tractography. Multimodal magnetic resonance imaging employing functional, diffusion and volumetric techniques were used to quantitatively assess the cognitive and neuroanatomical features of spatial working memory processes in 22q11DS. Twenty-six participants with genetically confirmed 22q11DS aged between 9 and 52 years and 26 controls aged between 8 and 46 years, matched for age, gender, and handedness were recruited. People with 22q11DS have significant differences in spatial working memory functioning accompanied by a gray matter volume reduction in the right precuneus. Gray matter volume was significantly correlated with task performance scores in these areas. Tractography revealed extensive differences along fibers between task-related cortical activations with pronounced differences localized to interhemispheric commissural fibers within the parietal section of the corpus callosum. Abnormal spatial working memory in 22q11DS is associated with aberrant functional activity in conjunction with gray and white matter structural abnormalities. These anomalies in discrete brain regions may increase susceptibility to the development of psychiatric disorders such as schizophrenia. Hum Brain Mapp, 2016. © 2016 Wiley Periodicals, Inc.
Collections Ireland -> Royal College of Surgeons in Ireland -> PubMed

Full list of authors on original publication

Kieran C Murphy, Hugh Garavan, Colm McDonald, Alexander Leemans, Jane McGrath, Sarah Prasad, Sarah Howley, Erik O'Hanlon

Experts in our system

1
Kieran C Murphy
Royal College of Surgeons in Ireland
Total Publications: 28
 
2
Hugh Garavan
Trinity College Dublin
Total Publications: 160
 
3
Colm McDonald
National University of Ireland Galway
Total Publications: 45
 
4
Alexander Leemans
National University of Ireland Galway
Total Publications: 12
 
5
Jane Mcgrath
Trinity College Dublin
Total Publications: 11
 
6
Erik O'Hanlon
Royal College of Surgeons in Ireland
Total Publications: 16