Type

Journal Article

Authors

Thomas M Freiman
David C Henshall
Felix Rosenow
Volker Seifert
Camille Allene
Adriano A Cattani

Subjects

Biochemistry

Topics
micrornas epilepsy temporal lobe cell migration involvement cell apoptosis brain injury cell differentiation cell proliferation

Involvement of microRNAs in epileptogenesis. (2016)

Abstract Patients who have sustained brain injury or had developmental brain lesions present a non-negligible risk for developing delayed epilepsy. Finding therapeutic strategies to prevent development of epilepsy in at-risk patients represents a crucial medical challenge. Noncoding microRNA molecules (miRNAs) are promising candidates in this area. Indeed, deregulation of diverse brain-specific miRNAs has been observed in animal models of epilepsy as well as in patients with epilepsy, mostly in temporal lobe epilepsy (TLE). Herein we review deregulated miRNAs reported in epilepsy with potential roles in key molecular and cellular processes underlying epileptogenesis, namely neuroinflammation, cell proliferation and differentiation, migration, apoptosis, and synaptic remodeling. We provide an up-to-date listing of miRNAs altered in epileptogenesis and assess recent functional studies that have interrogated their role in epilepsy. Last, we discuss potential applications of these findings for the future development of disease-modifying therapeutic strategies for antiepileptogenesis.
Collections Ireland -> Royal College of Surgeons in Ireland -> PubMed

Full list of authors on original publication

Thomas M Freiman, David C Henshall, Felix Rosenow, Volker Seifert, Camille Allene, Adriano A Cattani

Experts in our system

1
David C Henshall
Royal College of Surgeons in Ireland
Total Publications: 127
 
2
Felix Rosenow
Royal College of Surgeons in Ireland
Total Publications: 8