Type

Journal Article

Authors

Kristen J Brennand
Gang Fang
David Cotter
Manuel Mattheisen
Pamela Sklar
Joel T Dudley
Fred H Gage
Judith Rapoport
Gerard Cagney
Hardik Shah
and 14 others

Subjects

Medicine & Nursing

Topics
schizophrenia progenitor cells patients disease risk mirna diagnosis migration rna seq

Dysregulation of miRNA-9 in a Subset of Schizophrenia Patient-Derived Neural Progenitor Cells. (2015)

Abstract Converging evidence indicates that microRNAs (miRNAs) may contribute to disease risk for schizophrenia (SZ). We show that microRNA-9 (miR-9) is abundantly expressed in control neural progenitor cells (NPCs) but also significantly downregulated in a subset of SZ NPCs. We observed a strong correlation between miR-9 expression and miR-9 regulatory activity in NPCs as well as between miR-9 levels/activity, neural migration, and diagnosis. Overexpression of miR-9 was sufficient to ameliorate a previously reported neural migration deficit in SZ NPCs, whereas knockdown partially phenocopied aberrant migration in control NPCs. Unexpectedly, proteomic- and RNA sequencing (RNA-seq)-based analysis revealed that these effects were mediated primarily by small changes in expression of indirect miR-9 targets rather than large changes in direct miR-9 targets; these indirect targets are enriched for migration-associated genes. Together, these data indicate that aberrant levels and activity of miR-9 may be one of the many factors that contribute to SZ risk, at least in a subset of patients.
Collections Ireland -> Royal College of Surgeons in Ireland -> PubMed

Full list of authors on original publication

Kristen J Brennand, Gang Fang, David Cotter, Manuel Mattheisen, Pamela Sklar, Joel T Dudley, Fred H Gage, Judith Rapoport, Gerard Cagney, Hardik Shah and 14 others

Experts in our system

1
David R Cotter
Royal College of Surgeons in Ireland
Total Publications: 56
 
2
Gerard Cagney
Royal College of Surgeons in Ireland
Total Publications: 54