Type

Journal Article

Authors

Fergal D Malone
Dermot Kenny
Michael P Geary
Elizabeth Tully
Patrick Dicker
Mark Dempsey
Morgan Kearney
Brian Cotter
Hugh O'connor
Jonathan Cowman
and 3 others

Subjects

Pharmacology

Topics
diagnosis arachidonic acid disease fetal weight birth weight platelet adenosine diphosphate gestational hypertension

Altered Platelet Function in Intrauterine Growth Restriction: A Cause or a Consequence of Uteroplacental Disease? (2016)

Abstract Objective A limited number of platelet function studies in intrauterine growth restriction (IUGR) have yielded conflicting results. We sought to evaluate platelet reactivity in IUGR using a novel platelet aggregation assay. Study Design Pregnancies with IUGR were recruited from 24 weeks' gestation (estimated fetal weight < 10th centile) and had platelet function testing performed after diagnosis. A modification of light transmission aggregometry created dose-response curves of platelet reactivity in response to multiple agonists at differing concentrations. Findings were compared with healthy third trimester controls. IUGR cases with a subsequent normal birth weight were analyzed separately. Results In this study, 33 pregnancies retained their IUGR diagnosis at birth, demonstrating significantly reduced platelet reactivity in response to all agonists (arachidonic acid, adenosine diphosphate, collagen, thrombin receptor-activating peptide, and epinephrine) when compared with 36 healthy pregnancy controls (p < 0.0001). Similar results were obtained for cases demonstrating an increasing in utero growth trajectory. When IUGR preceded preeclampsia or gestational hypertension, platelet function was significantly reduced compared with normotensive IUGR. Conclusion Using this comprehensive platelet assay, we have demonstrated a functional impairment of platelets in IUGR. This may reflect platelet-derived placental growth factor release. Further evaluation of platelet function may aid in the development of future platelet-targeted therapies for uteroplacental disease.
Collections Ireland -> Royal College of Surgeons in Ireland -> PubMed

Full list of authors on original publication

Fergal D Malone, Dermot Kenny, Michael P Geary, Elizabeth Tully, Patrick Dicker, Mark Dempsey, Morgan Kearney, Brian Cotter, Hugh O'connor, Jonathan Cowman and 3 others

Experts in our system

1
Fergal D Malone
Royal College of Surgeons in Ireland
Total Publications: 73
 
2
Dermot Kenny
Royal College of Surgeons in Ireland
 
3
MIchael Geary
Royal College of Surgeons in Ireland
Total Publications: 41
 
4
Elizabeth Tully
Royal College of Surgeons in Ireland
Total Publications: 28
 
5
Patrick Dicker
Royal College of Surgeons in Ireland
Total Publications: 95
 
6
M A Dempsey
Royal College of Surgeons in Ireland
Total Publications: 8
 
7
Brian Cotter
Royal College of Surgeons in Ireland
 
8
Jonathan Cowman
Royal College of Surgeons in Ireland
Total Publications: 3