Journal Article


Carlos E Castro
Fergal J O'Brien
Christopher R Lucas
Cathal J Kearney



direct shape control biomedical applications structures drug delivery behavior cell dna

DNA Origami: Folded DNA-Nanodevices That Can Direct and Interpret Cell Behavior. (2015)

Abstract DNA origami is a DNA-based nanotechnology that utilizes programmed combinations of short complementary oligonucleotides to fold a large single strand of DNA into precise 2D and 3D shapes. The exquisite nanoscale shape control of this inherently biocompatible material is combined with the potential to spatially address the origami structures with diverse cargoes including drugs, antibodies, nucleic acid sequences, small molecules, and inorganic particles. This programmable flexibility enables the fabrication of precise nanoscale devices that have already shown great potential for biomedical applications such as: drug delivery, biosensing, and synthetic nanopore formation. Here, the advances in the DNA-origami field since its inception several years ago are reviewed with a focus on how these DNA-nanodevices can be designed to interact with cells to direct or probe their behavior.
Collections Ireland -> Royal College of Surgeons in Ireland -> PubMed

Full list of authors on original publication

Carlos E Castro, Fergal J O'Brien, Christopher R Lucas, Cathal J Kearney

Experts in our system

Fergal J O'Brien
Royal College of Surgeons in Ireland
Total Publications: 268
Cathal J Kearney
Royal College of Surgeons in Ireland
Total Publications: 14