Type

Journal Article

Authors

Paul D. Cotter
R. Paul Ross
Colin Hill
Orla O'Sullivan
Paula M O'Connor
Elaine M Lawton
Caitriona M Guinane

Subjects

Microbiology

Topics
gastrointestinal tract human health antimicrobial peptides populations microbial gut microbiota microbial diversity lactobacillus salivarius

The bacteriocin bactofencin A subtly modulates gut microbial populations. (2016)

Abstract The diverse and dynamic microbiota of the gastrointestinal tract represents a vast source of bioactive substances. These include bacteriocins, which are antimicrobial peptides with the potential to modulate gut populations to impact positively on human health. Although several gut-derived bacteriocins have been isolated, there remain only a few exceptional studies in which their influence on microbial populations within the gut has been investigated. To facilitate such investigations, in vitro faecal fermentation systems can be used to simulate the anaerobic environment of the colon. In this instance, such a system was employed to explore the impact of bactofencin A, a novel broad spectrum class IId bacteriocin produced by gut isolates of Lactobacillus salivarius, on intestinal populations and overall microbial diversity. The study reveals that, although bactofencin A is a broad spectrum bacteriocin, it has a relatively subtle influence on intestinal communities, with a potentially positive impact on anaerobic populations such as Bacteroides, Clostridium and Bifidibacterium spp. The strategy taken is an important first step in investigating the merits of using bactofencin A to manipulate the gut microbiota in a beneficial way for health.
Collections Ireland -> Teagasc -> PubMed

Full list of authors on original publication

Paul D. Cotter, R. Paul Ross, Colin Hill, Orla O'Sullivan, Paula M O'Connor, Elaine M Lawton, Caitriona M Guinane

Experts in our system

1
Paul D. Cotter
Teagasc
Total Publications: 253
 
2
R Paul Ross
Teagasc
Total Publications: 441
 
3
Colin Hill
University College Cork
Total Publications: 351
 
4
Orla O'Sullivan
Teagasc
Total Publications: 92
 
5
Paula M. O'Connor
Teagasc
Total Publications: 85
 
6
Elaine M. Lawton
University College Cork
Total Publications: 12
 
7
Caitriona M Guinane
Teagasc
Total Publications: 35