Type

Journal Article

Authors

Miguel Gueimonde
Marco Ventura
Clara G de Los Reyes-Gavilán
Abelardo Margolles
Christian Milani
Ana M Hernández-Barranco
Marta Suárez
Nuria Fernández
Gonzalo Solís
Borja Sanchez
and 1 others

Subjects

Microbiology

Topics
antibiotics 16s rrna gas chromatography mass spectrometry perinatal fatty acids inference health intestinal microbiota

Impact of Prematurity and Perinatal Antibiotics on the Developing Intestinal Microbiota: A Functional Inference Study. (2016)

Abstract The microbial colonization of the neonatal gut provides a critical stimulus for normal maturation and development. This process of early microbiota establishment, known to be affected by several factors, constitutes an important determinant for later health. We studied the establishment of the microbiota in preterm and full-term infants and the impact of perinatal antibiotics upon this process in premature babies. To this end, 16S rRNA gene sequence-based microbiota assessment was performed at phylum level and functional inference analyses were conducted. Moreover, the levels of the main intestinal microbial metabolites, the short-chain fatty acids (SCFA) acetate, propionate and butyrate, were measured by Gas-Chromatography Flame ionization/Mass spectrometry detection. Prematurity affects microbiota composition at phylum level, leading to increases of Proteobacteria and reduction of other intestinal microorganisms. Perinatal antibiotic use further affected the microbiota of the preterm infant. These changes involved a concomitant alteration in the levels of intestinal SCFA. Moreover, functional inference analyses allowed for identifying metabolic pathways potentially affected by prematurity and perinatal antibiotics use. A deficiency or delay in the establishment of normal microbiota function seems to be present in preterm infants. Perinatal antibiotic use, such as intrapartum prophylaxis, affected the early life microbiota establishment in preterm newborns, which may have consequences for later health.
Collections Ireland -> Teagasc -> PubMed

Full list of authors on original publication

Miguel Gueimonde, Marco Ventura, Clara G de Los Reyes-Gavilán, Abelardo Margolles, Christian Milani, Ana M Hernández-Barranco, Marta Suárez, Nuria Fernández, Gonzalo Solís, Borja Sanchez and 1 others

Experts in our system

1
Miguel Gueimonde
Teagasc
Total Publications: 6
 
2
Marco Ventura
University College Cork
Total Publications: 31
 
4
Abelardo Margolles
University College Cork
 
5
Christian Milani
University College Cork
Total Publications: 9
 
6
Marta Suárez
Teagasc
Total Publications: 3
 
7
Nuria Fernández
Teagasc
Total Publications: 3
 
8
Gonzalo Solís
Teagasc
Total Publications: 3
 
9
Borja Sanchez
Teagasc