Type

Journal Article

Authors

Joanne Lysaght
John V Reynolds
Cliona O'Farrelly
Niamh Gilmartin
Suzanne L Doyle
Ann Marie Mongan
Maria E Kavanagh
Karen C Galvin
Melissa J Conroy

Subjects

Biochemistry

Topics
cell migration t cell cardiovascular disease global health diabetes mellitus type 2 cd4 t cells cell biology cancer cell

CCR1 antagonism attenuates T cell trafficking to omentum and liver in obesity-associated cancer. (2016)

Abstract Obesity is a global health problem presenting serious risk of disease fuelled by chronic inflammation, including type 2 diabetes mellitus, cardiovascular disease, liver disease and cancer. Visceral fat, in particular the omentum and liver of obese individuals are sites of excessive inflammation. We propose that chemokine-mediated trafficking of pro-inflammatory cells to the omentum and liver contributes to local and subsequent systemic inflammation. Oesophagogastric adenocarcinoma (OAC) is an exemplar model of obesity and inflammation driven cancer. We have demonstrated that T cells actively migrate to the secreted factors from the omentum and liver of OAC patients and that both CD4(+) and CD8(+) T cells bearing the chemokine receptor CCR5 are significantly more prevalent in these tissues compared to matched blood. The CCR5 ligand and inflammatory chemokine MIP-1α is also secreted at significantly higher concentrations in the omentum and liver of our OAC patient cohort compared to matched serum. Furthermore, we report that MIP-1α receptor antagonism can significantly reduce T cell migration to the secreted factors from OAC omentum and liver. These novel data suggest that chemokine receptor antagonism may have therapeutic potential to reduce inflammatory T cell infiltration to the omentum and liver and in doing so, may ameliorate pathological inflammation in obesity and obesity-associated cancer.Immunology and Cell Biology advance online publication, 5 April 2016; doi:10.1038/icb.2016.26.
Collections Ireland -> Trinity College Dublin -> PubMed

Full list of authors on original publication

Joanne Lysaght, John V Reynolds, Cliona O'Farrelly, Niamh Gilmartin, Suzanne L Doyle, Ann Marie Mongan, Maria E Kavanagh, Karen C Galvin, Melissa J Conroy

Experts in our system

1
Joanne Lysaght
Trinity College Dublin
Total Publications: 39
 
2
J V Reynolds
Trinity College Dublin
Total Publications: 206
 
3
Cliona O'Farrelly
Trinity College Dublin
Total Publications: 147
 
4
Niamh Gilmartin
TU Dublin
Total Publications: 6
 
5
Suzanne L Doyle
Trinity College Dublin
Total Publications: 23
 
6
Ann-Marie Mongan
Trinity College Dublin
Total Publications: 6
 
7
Melissa J Conroy
Trinity College Dublin
Total Publications: 14