Type

Journal Article

Authors

Gunter Schumann
Herta Flor
Adrian Rothenfluh
Jianfeng Feng
Christian P Müller
Michael N Smolka
Trevor Robbins
Marcella Rietschel
Jean-Baptiste Poline
Zdenka Pausova
and 25 others

Subjects

Psychiatry

Topics
alcohol consumption genetic attention deficit hyperactivity disorder adhd mental disorders reward network humans brain

Neural basis of reward anticipation and its genetic determinants. (2016)

Abstract Dysfunctional reward processing is implicated in various mental disorders, including attention deficit hyperactivity disorder (ADHD) and addictions. Such impairments might involve different components of the reward process, including brain activity during reward anticipation. We examined brain nodes engaged by reward anticipation in 1,544 adolescents and identified a network containing a core striatal node and cortical nodes facilitating outcome prediction and response preparation. Distinct nodes and functional connections were preferentially associated with either adolescent hyperactivity or alcohol consumption, thus conveying specificity of reward processing to clinically relevant behavior. We observed associations between the striatal node, hyperactivity, and thevacuolar protein sorting-associated protein 4A(VPS4A) gene in humans, and the causal role ofVps4for hyperactivity was validated inDrosophila Our data provide a neurobehavioral model explaining the heterogeneity of reward-related behaviors and generate a hypothesis accounting for their enduring nature.
Collections Ireland -> Trinity College Dublin -> PubMed

Full list of authors on original publication

Gunter Schumann, Herta Flor, Adrian Rothenfluh, Jianfeng Feng, Christian P Müller, Michael N Smolka, Trevor Robbins, Marcella Rietschel, Jean-Baptiste Poline, Zdenka Pausova and 25 others

Experts in our system

1
Gunter Schumann
Trinity College Dublin
Total Publications: 65
 
2
Herta Flor
Trinity College Dublin
Total Publications: 66
 
3
Michael N Smolka
Trinity College Dublin
Total Publications: 65
 
4
Trevor W Robbins
Trinity College Dublin
Total Publications: 25
 
5
Marcella Rietschel
Trinity College Dublin
Total Publications: 40