Type

Journal Article

Authors

Hugh Garavan
Robert R Althoff
Gunter Schumann
Robert Whelan
Henrik Walter
Sarah Jurk
Michael N Smolka
Luise Poustka
Dimitri Papadopoulos-Orfanos
Frauke Nees
and 21 others

Subjects

Psychology

Topics
voxel based morphometry anterior thalamus individual differences substance use environmental factors life events brain adolescent behavior

Brain Regions Related to Impulsivity Mediate the Effects of Early Adversity on Antisocial Behavior. (2015)

Abstract Individual differences in impulsivity and early adversity are known to be strong predictors of adolescent antisocial behavior. However, the neurobiological bases of impulsivity and their relation to antisocial behavior and adversity are poorly understood. Impulsivity was estimated with a temporal discounting task. Voxel-based morphometry was used to determine the brain structural correlates of temporal discounting in a large cohort (n = 1830) of 14- to 15-year-old children. Mediation analysis was then used to determine whether the volumes of brain regions associated with temporal discounting mediate the relation between adverse life events (e.g., family conflict, serious accidents) and antisocial behaviors (e.g., precocious sexual activity, bullying, illicit substance use). Greater temporal discounting (more impulsivity) was associated with 1) lower volume in frontomedial cortex and bilateral insula and 2) greater volume in a subcortical region encompassing the ventral striatum, hypothalamus and anterior thalamus. The volume ratio between these cortical and subcortical regions was found to partially mediate the relation between adverse life events and antisocial behavior. Temporal discounting is related to regions of the brain involved in reward processing and interoception. The results support a developmental imbalance model of impulsivity and are consistent with the idea that negative environmental factors can alter the developing brain in ways that promote antisocial behavior.
Collections Ireland -> Trinity College Dublin -> PubMed

Full list of authors on original publication

Hugh Garavan, Robert R Althoff, Gunter Schumann, Robert Whelan, Henrik Walter, Sarah Jurk, Michael N Smolka, Luise Poustka, Dimitri Papadopoulos-Orfanos, Frauke Nees and 21 others

Experts in our system

1
Hugh Garavan
Trinity College Dublin
Total Publications: 170
 
2
Gunter Schumann
Trinity College Dublin
Total Publications: 65
 
3
Robert Whelan
Trinity College Dublin
Total Publications: 80
 
4
Michael N Smolka
Trinity College Dublin
Total Publications: 65
 
5
Frauke Nees
Trinity College Dublin
Total Publications: 63