Type

Journal Article

Authors

Thomas Frodl
Veronica O'Keane
Anton Lord
John Gormley
Hazel McCarthy
Francesco Amico
Myles Doyle
Kelly Doolin
Grace Lavelle
Angela Carballedo
and 1 others

Subjects

Physiotherapy & Sport

Topics
aerobic exercise exercise magnetic resonance imaging functional connectivity randomized controlled trial physical exercise physical activity brain function

Longitudinal functional connectivity changes correlate with mood improvement after regular exercise in a dose-dependent fashion. (2016)

Abstract Exercise increases wellbeing and improves mood. It is however unclear how these mood changes relate to brain function. We conducted a randomized controlled trial investigating resting-state modifications in healthy adults after an extended period of aerobic physical exercise and their relationship with mood improvements. We aimed to identify novel functional networks whose activity could provide a physiological counterpart to the mood-related benefits of exercise. Thirty-eight healthy sedentary volunteers were randomised to either the aerobic exercise group of the study or a control group. Participants in the exercise group attended aerobic sessions with a physiotherapist twice a week for 16 weeks. Resting-state modifications using magnetic resonance imaging were assessed before and after the programme and related to mood changes. An unbiased approach using graph metrics and network-based statistics was adopted. Exercise reduced mood disturbance and improved emotional wellbeing. It also induced a decrease in local efficiency in the parahippocampal lobe through strengthening of the functional connections from this structure to the supramarginal gyrus, precentral area, superior temporal gyrus and temporal pole. Changes in mood disturbance following exercise were correlated with those in connectivity between parahippocampal gyrus and superior temporal gyrus as well as with the amount of training. No changes were detected in the control group. In conclusion, connectivity from the parahippocampal gyrus to motor, sensory integration and mood regulation areas was strengthened through exercise. These functional changes might be related to the benefits of regular physical activity on mood.
Collections Ireland -> Trinity College Dublin -> PubMed

Full list of authors on original publication

Thomas Frodl, Veronica O'Keane, Anton Lord, John Gormley, Hazel McCarthy, Francesco Amico, Myles Doyle, Kelly Doolin, Grace Lavelle, Angela Carballedo and 1 others

Experts in our system

1
Thomas Frodl
Trinity College Dublin
Total Publications: 58
 
2
Veronica O'Keane
Trinity College Dublin
Total Publications: 15
 
3
John Gormley
Trinity College Dublin
Total Publications: 21
 
4
Hazel McCarthy
Trinity College Dublin
Total Publications: 8
 
5
Francesco Amico
Trinity College Dublin
Total Publications: 8
 
6
Kelly Doolin
Trinity College Dublin
 
7
Angela Carballedo
Trinity College Dublin
Total Publications: 23