Type

Journal Article

Authors

Jürgen Gallinat
Andreas Heinz
Gunter Schumann
Rüdiger Brühl
Andreas Ströhle
Michael N Smolka
Marcella Rietschel
Tomáš Paus
Jean-Luc Martinot
Karl Mann
and 10 others

Subjects

Psychology

Topics
behaviour alcohol use risk factor drinking magnetic resonance imaging alcohol consumption alcohol exposure mother and child

From mother to child: orbitofrontal cortex gyrification and changes of drinking behaviour during adolescence. (2015)

Abstract Adolescence is a common time for initiation of alcohol use and alcohol use disorders. Importantly, the neuro-anatomical foundation for later alcohol-related problems may already manifest pre-natally, particularly due to smoking and alcohol consumption during pregnancy. In this context, cortical gyrification is an interesting marker of neuronal development but has not been investigated as a risk factor for adolescent alcohol use. On magnetic resonance imaging scans of 595 14-year-old adolescents from the IMAGEN sample, we computed whole-brain mean curvature indices to predict change in alcohol-related problems over the following 2 years. Change of alcohol use-related problems was significantly predicted from mean curvature in left orbitofrontal cortex (OFC). Less gyrification of OFC was associated with an increase in alcohol use-related problems over the next 2 years. Moreover, lower gyrification in left OFC was related to pre-natal alcohol exposure, whereas maternal smoking during pregnancy had no effect. Current alcohol use-related problems of the biological mother had no effect on offsprings' OFC gyrification or drinking behaviour. The data support the idea that alcohol consumption during pregnancy mediates the development of neuro-anatomical phenotypes, which in turn constitute a risk factor for increasing problems due to alcohol consumption in a vulnerable stage of life. Maternal smoking during pregnancy or current maternal alcohol/nicotine consumption had no significant effect. The OFC mediates behaviours known to be disturbed in addiction, namely impulse control and reward processing. The results stress the importance of pre-natal alcohol exposure for later increases in alcohol use-related problems, mediated by structural brain characteristics.
Collections Ireland -> Trinity College Dublin -> PubMed

Full list of authors on original publication

Jürgen Gallinat, Andreas Heinz, Gunter Schumann, Rüdiger Brühl, Andreas Ströhle, Michael N Smolka, Marcella Rietschel, Tomáš Paus, Jean-Luc Martinot, Karl Mann and 10 others

Experts in our system

1
Jurgen Gallinat
Trinity College Dublin
Total Publications: 35
 
2
Andreas Heinz
Trinity College Dublin
Total Publications: 55
 
3
Gunter Schumann
Trinity College Dublin
Total Publications: 55
 
4
Michael N Smolka
Trinity College Dublin
Total Publications: 56
 
5
Marcella Rietschel
Trinity College Dublin
Total Publications: 40
 
6
Tomas Paus
Trinity College Dublin
Total Publications: 56
 
7
Jean-Luc Martinot
Trinity College Dublin
Total Publications: 45