Type

Journal Article

Authors

Hanne C Bertram
Alan L Kelly
C Anthony Ryan
Carol-Anne O'Shea
James A O'Mahony
Eimear Downey
Ulrik K Sundekilde

Subjects

Chemistry

Topics
nutritional requirements magnetic resonance spectroscopy nuclear magnetic resonance nmr gestational age human milk nutrition metabolomics metabolite profiling metabolome infant metabolites pre term milk human nmr spectroscopy

The Effect of Gestational and Lactational Age on the Human Milk Metabolome. (2016)

Abstract Human milk is the ideal nutrition source for healthy infants during the first six months of life and a detailed characterisation of the composition of milk from mothers that deliver prematurely (<37 weeks gestation), and of how human milk changes during lactation, would benefit our understanding of the nutritional requirements of premature infants. Individual milk samples from mothers delivering prematurely and at term were collected. The human milk metabolome, established by nuclear magnetic resonance (NMR) spectroscopy, was influenced by gestational and lactation age. Metabolite profiling identified that levels of valine, leucine, betaine, and creatinine were increased in colostrum from term mothers compared with mature milk, while those of glutamate, caprylate, and caprate were increased in mature term milk compared with colostrum. Levels of oligosaccharides, citrate, and creatinine were increased in pre-term colostrum, while those of caprylate, caprate, valine, leucine, glutamate, and pantothenate increased with time postpartum. There were differences between pre-term and full-term milk in the levels of carnitine, caprylate, caprate, pantothenate, urea, lactose, oligosaccharides, citrate, phosphocholine, choline, and formate. These findings suggest that the metabolome of pre-term milk changes within 5-7 weeks postpartum to resemble that of term milk, independent of time of gestation at pre-mature delivery.
Collections Ireland -> University College Cork -> Paediatrics and Child Health - Journal Articles
Ireland -> University College Cork -> PubMed
Ireland -> University College Cork -> College of Science, Engineering and Food Science
Ireland -> University College Cork -> Food and Nutritional Sciences - Journal Articles
Ireland -> University College Cork -> College of Medicine and Health
Ireland -> University College Cork -> Food and Nutritional Sciences
Ireland -> University College Cork -> Paediatrics & Child Health

Full list of authors on original publication

Hanne C Bertram, Alan L Kelly, C Anthony Ryan, Carol-Anne O'Shea, James A O'Mahony, Eimear Downey, Ulrik K Sundekilde

Experts in our system

1
Alan L. Kelly
Teagasc
Total Publications: 63
 
2
Cristín Ryan
University College Cork
Total Publications: 110
 
3
Carol-Anne O'Shea
Teagasc
Total Publications: 10
 
4
James A. O'Mahony
Teagasc
Total Publications: 34