Type

Journal Article

Authors

Edmund J S Sonuga-Barke
Alessandro Zuddas
Ian C K Wong
Margaret Thompson
Peter Nagy
Suzanne McCarthy
Elizabeth Liddle
Kerstin Konrad
Sarah Inglis
Chris Hollis
and 9 others

Subjects

Psychiatry

Topics
medication adherence generation field testing attention deficit hyperactivity disorder adhd treatment outcome content analysis cognition literature search

Reports of Perceived Adverse Events of Stimulant Medication on Cognition, Motivation, and Mood: Qualitative Investigation and the Generation of Items for the Medication and Cognition Rating Scale. (2016)

Abstract There is no questionnaire to specifically monitor perceived adverse events of methylphenidate (MPH) on cognition, motivation, and mood. The current study therefore had two goals. First, to harvest accounts of such putative events from transcripts of interviews in samples enriched for such potential experiences. Second, to use the derived data to generate items for a new questionnaire that can be used for monitoring such events in medication trials or routine clinical care. Following a literature search aimed at identifying associations between MPH and cognition and/or motivation, a qualitative semistructured interview was designed to focus specifically on the domains of cognition (i.e., reasoning, depth/breadth of thinking, intellectual capacity, and creativity) and motivation (i.e., drive, effort, and attitudes toward rewards/incentives). Interviews were conducted with 45 participants drawn from the following four groups: (a) clinicians, child and adolescent psychiatrists, and pediatricians specializing in attention-deficit/hyperactivity disorder (ADHD) (n = 15); (2) teachers, with experience of teaching at least 10 medicated children with ADHD (n = 10); (3) parents of children with ADHD (n = 8) treated with MPH; and (4) adolescents/adults with ADHD (n = 12). Purposeful sampling was used to selectively recruit ADHD participants whose histories suggested a degree of vulnerability to MPH adverse events. Data were analyzed using a deductive approach to content analysis. While we probed purposefully for cognitive and motivational adverse events, a third domain, related to mood, emerged from the reports. Therefore, three domains, each with a number of subdomains, were identified from the interview accounts: (i) Cognition (six subdomains; attention/concentration, changes in thinking, reduced creativity, sensory overload, memory, slower processing speed); (ii) motivation (four subdomains; loss of intrinsic motivation for goal-directed activities, external locus of control, lack of effort/engagement in daily tasks, increased focus on incentives); and (iii) mood (three subdomains; dampening of spontaneity/flat affect, mood dysregulation, increased anxiety/edginess). On the basis of these reports, 34 items were specified and incorporated into a prototype questionnaire, which was piloted and refined on the basis of field-testing. Items were identified that capture potential/perceived cognitive, motivational, and mood-related adverse events of MPH. The items generated will allow us to further develop and psychometrically examine their prevalence, and the extent to which they are associated with medication adherence, treatment outcome, impairment, and other reported adverse events (e.g., loss of appetite/cardiovascular effects).
Collections Ireland -> University College Cork -> PubMed

Full list of authors on original publication

Edmund J S Sonuga-Barke, Alessandro Zuddas, Ian C K Wong, Margaret Thompson, Peter Nagy, Suzanne McCarthy, Elizabeth Liddle, Kerstin Konrad, Sarah Inglis, Chris Hollis and 9 others

Experts in our system

1
Edmund Sonuga-Barke
University College Cork
Total Publications: 7
 
2
Alessandro Zuddas
University College Cork
Total Publications: 4
 
3
Ian C K Wong
University College Cork
Total Publications: 10
 
4
Peter Nagy
University College Cork
Total Publications: 4
 
5
Suzanne McCarthy
University College Cork
Total Publications: 34
 
6
E Liddle
University College Cork
Total Publications: 4
 
7
C Hollis
University College Cork
Total Publications: 5