Type

Journal Article

Authors

Eileen R Gibney
Fionnuala M McAuliffe
Goiuri Alberdi
Karen L Lindsay
Aisling A Geraghty

Subjects

Veterinary

Topics
animal studies pregnancy animal this review growth and development human dna methylation animal nutrition b vitamins

Nutrition During Pregnancy Impacts Offspring's Epigenetic Status-Evidence from Human and Animal Studies. (2015)

Abstract Pregnancy is a vital time of growth and development during which maternal nutrition significantly influences the future health of both mother and baby. During pregnancy, the fetus experiences a critical period of plasticity. Epigenetics, specifically DNA methylation, plays an important role here. As nutrition is influential for DNA methylation, this review aims to determine if maternal nutrition during pregnancy can modify the offspring's epigenome at birth. Research focuses on micronutrients and methyl donors such as folate and B vitamins. Evidence suggests that maternal nutrition does not largely influence global methylation patterns, particularly in nutrient-replete populations; however, an important impact on gene-specific methylation is observed. A link is shown between maternal nutrition and the methylome of the offspring; however, there remains a paucity of research. With the potential to use DNA methylation patterns at birth to predict health of the child in later life, it is vital that further research be carried out.
Collections Ireland -> University College Dublin -> PubMed

Full list of authors on original publication

Eileen R Gibney, Fionnuala M McAuliffe, Goiuri Alberdi, Karen L Lindsay, Aisling A Geraghty

Experts in our system

1
Eileen R Gibney
University College Dublin
Total Publications: 98
 
2
Fionnuala M McAuliffe
University College Dublin
Total Publications: 176
 
3
Goiuri Alberdi
University College Dublin
Total Publications: 9
 
4
Karen L Lindsay
University College Dublin
Total Publications: 19
 
5
Aisling A Geraghty
University College Dublin