Journal Article


Robert W Welch
Lalit Garg
Jane L Ward
Peter R Shewry
Mike J Gibney
J J Strain
Julie M W Wallace
Ruth K Price
Lorraine Brennan
Ramandeep Garg


Physiotherapy & Sport

energy metabolism minimally processed consumption wheat metabolomics women nmr postprandial

Using NMR-Based Metabolomics to Evaluate Postprandial Urinary Responses Following Consumption of Minimally Processed Wheat Bran or Wheat Aleurone by Men and Women. (2015)

Abstract Wheat bran, and especially wheat aleurone fraction, are concentrated sources of a wide range of components which may contribute to the health benefits associated with higher consumption of whole-grain foods. This study used NMR metabolomics to evaluate urine samples from baseline at one and two hours postprandially, following the consumption of minimally processed bran, aleurone or control by 14 participants (7 Females; 7 Males) in a randomized crossover trial. The methodology discriminated between the urinary responses of control, and bran and aleurone, but not between the two fractions. Compared to control, consumption of aleurone or bran led to significantly and substantially higher urinary concentrations of lactate, alanine, N-acetylaspartate acid and N-acetylaspartylglutamate and significantly and substantially lower urinary betaine concentrations at one and two hours postprandially. There were sex related differences in urinary metabolite profiles with generally higher hippurate and citrate and lower betaine in females compared to males. Overall, this postprandial study suggests that acute consumption of bran or aleurone is associated with a number of physiological effects that may impact on energy metabolism and which are consistent with longer term human and animal metabolomic studies that used whole-grain wheat diets or wheat fractions.
Collections Ireland -> University College Dublin -> PubMed

Full list of authors on original publication

Robert W Welch, Lalit Garg, Jane L Ward, Peter R Shewry, Mike J Gibney, J J Strain, Julie M W Wallace, Ruth K Price, Lorraine Brennan, Ramandeep Garg

Experts in our system

Mike Gibney
University College Dublin
Total Publications: 24
J J Strain
Trinity College Dublin
Total Publications: 12
Lorraine Brennan
University College Dublin
Total Publications: 166