Journal Article


Bryan Markey
Stephen V Gordon
Jim O'Donovan
Joseph P Cassidy
Louise E Britton


Medicine & Nursing

public health this review chronic disease diagnosis protein expression diagnostic tests johne s disease mycobacterium avium subspecies paratuberculosis

Potential application of emerging diagnostic techniques to the diagnosis of bovine Johne's disease (paratuberculosis). (2014)

Abstract Mycobacterium avium subspecies paratuberculosis (MAP) causes Johne's disease (paratuberculosis), a chronic wasting disease in cattle with important welfare, economic and potential public health implications. Current tests are unable to recognise all stages of the disease, which makes it difficult to diagnose and control. This review explores emerging diagnostic techniques that could complement and enhance the diagnosis of MAP infection, including bacteriophage analysis, new MAP-specific antigens, host protein expression in response to infection, transcriptomic studies, analysis of microRNAs and investigation of the gastrointestinal microbiome. It emphasises the inherent challenges of diagnosing bovine Johne's disease and investigates novel areas which may have the potential both to advance our understanding of the immunopathology of MAP infection and to augment current diagnostic tests.
Collections Ireland -> University College Dublin -> PubMed

Full list of authors on original publication

Bryan Markey, Stephen V Gordon, Jim O'Donovan, Joseph P Cassidy, Louise E Britton

Experts in our system

B K Markey
University College Dublin
Total Publications: 43
Stephen V. Gordon
University College Dublin
Total Publications: 40
Joseph P. Cassidy
University College Dublin
Total Publications: 55