Journal Article


Colin Hill
R. Paul Ross
Paul D. Cotter
Nynke Seisling
Des Field



antimicrobial peptides combinations antibiotic organic polymer nisin pseudomonas aeruginosa lantibiotic biofilm bacteriocin antibiotics biofilm formation colistin combination therapy p aeruginosa pseudomonas polymyxin

Synergistic nisin-polymyxin combinations for the control of Pseudomonas biofilm formation (2016)

Abstract The emergence and dissemination of multi-drug resistant pathogens is a global concern. Moreover, even greater levels of resistance are conferred on bacteria when in the form of biofilms (i.e., complex, sessile communities of bacteria embedded in an organic polymer matrix). For decades, antimicrobial peptides have been hailed as a potential solution to the paucity of novel antibiotics, either as natural inhibitors that can be used alone or in formulations with synergistically acting antibiotics. Here, we evaluate the potential of the antimicrobial peptide nisin to increase the efficacy of the antibiotics polymyxin and colistin, with a particular focus on their application to prevent biofilm formation of Pseudomonas aeruginosa. The results reveal that the concentrations of polymyxins that are required to effectively inhibit biofilm formation can be dramatically reduced when combined with nisin, thereby enhancing efficacy, and ultimately, restoring sensitivity. Such combination therapy may yield added benefits by virtue of reducing polymyxin toxicity through the administration of significantly lower levels of polymyxin antibiotics.
Collections Ireland -> Teagasc -> Food Biosciences
Ireland -> University College Cork -> Biochemistry and Cell Biology
Ireland -> Teagasc -> Food Biosciences
Ireland -> University College Cork -> College of Science, Engineering and Food Science
Ireland -> University College Cork -> Biochemistry and Cell Biology - Journal Articles
Ireland -> Teagasc -> Food Programme
Ireland -> Teagasc -> Food Programme

Full list of authors on original publication

Colin Hill, R. Paul Ross, Paul D. Cotter, Nynke Seisling, Des Field

Experts in our system

Colin Hill
University College Cork
Total Publications: 351
R Paul Ross
Total Publications: 441
Paul D. Cotter
Total Publications: 253
Des Field
Total Publications: 30