Type

Journal Article

Authors

Colin Hill
R. Paul Ross
Amanda Forde
Julie Callanan
Andrei Sorin Bolocan
Paul Ross

Subjects

Microbiology

Topics
this review targeting therapy phage steaec phage therapy aiec antibacterial agents escherichia coli story uti therapeutic use

Phage therapy targeting Escherichia coli - a story with no end? (2016)

Abstract Bacteriophages (phages) or bacterial viruses have long been proposed as an alternative therapy against antibiotic-resistant bacteria such as Escherichia coli. Even though poorly documented in the scientific literature, a long clinical history of phage therapy in countries such as Russia and Georgia suggests potential value in the use of phages as antibacterial agents. Escherichia coli is responsible for a wide range of diseases, intestinal (diarrhoea) and extraintestinal (UTI, septicaemia, pneumoniae, meningitis), making it an ideal target for phage therapy. This review discusses the latest research focusing on the potential of phage therapy to tackle E. coli-related illnesses. No intact phages are approved in EU or USA for human therapeutic use, but many successful in vitro and in vivo studies have been reported. However, additional research focused on in vivo multispecies models and human trials are required if phage therapy targeting E. coli pathotypes can be a story with happy end.
Collections Ireland -> University College Cork -> APC Microbiome Institute
Ireland -> University College Cork -> College of Science, Engineering and Food Science
Ireland -> University College Cork -> APC Microbiome Institute- Journal Articles
Ireland -> University College Cork -> Microbiology
Ireland -> University College Cork -> Research Institutes and Centres
Ireland -> University College Cork -> Microbiology - Journal Articles

Full list of authors on original publication

Colin Hill, R. Paul Ross, Amanda Forde, Julie Callanan, Andrei Sorin Bolocan, Paul Ross

Experts in our system

1
Colin Hill
University College Cork
Total Publications: 351
 
2
R Paul Ross
Teagasc
Total Publications: 441
 
3
Amanda Forde
University College Cork
Total Publications: 3
 
4
Paul Ross
University College Cork
Total Publications: 29