Type

Journal Article

Authors

Desmond M. Murphy
John MacSharry
Eoin Hunt
Ashley Sullivan

Subjects

Medicine & Nursing

Topics
translational research hygiene hypothesis pathophysiology treatment microbiology microbe dialogue epithelium asthma respiratory disease chronic disease host medicine inflammation molecular methods dna prevalence

The microbiome and the pathophysiology of asthma (2016)

Abstract Asthma is a chronic respiratory disease whose prevalence is increasing in the western world. Recently research has begun to focus on the role the microbiome plays in asthma pathogenesis in the hope of further understanding this respiratory disorder. Considered sterile until recently, the lungs have revealed themselves to contain a unique microbiota. A shift towards molecular methods for the quantification and sequencing of microbial DNA has revealed that the airways harbour a unique microbiota with apparent, reproducible differences present between healthy and diseased lungs. There is a hope that in classifying the microbial load of the asthmatic airway an insight may be afforded as to the possible role pulmonary microbes may have in propagating an asthmatic airway response. This could potentially pave the way for new therapeutic strategies for the treatment of chronic lung conditions such as asthma.
Collections Ireland -> University College Cork -> APC Microbiome Institute
Ireland -> University College Cork -> College of Science, Engineering and Food Science
Ireland -> University College Cork -> APC Microbiome Institute- Journal Articles
Ireland -> University College Cork -> Microbiology
Ireland -> University College Cork -> Research Institutes and Centres
Ireland -> University College Cork -> Microbiology - Journal Articles

Full list of authors on original publication

Desmond M. Murphy, John MacSharry, Eoin Hunt, Ashley Sullivan

Experts in our system

1
Desmond M. Murphy
University College Cork
Total Publications: 30
 
2
John MacSharry
University College Cork
Total Publications: 40
 
3
Eoin Hunt
University College Cork
Total Publications: 13
 
4
Ashley Sullivan
University College Cork
Total Publications: 5