Journal Article


Desmond M Murphy
Julie McCarthy
Barry J Plant
Lorraine Thong


Medicine & Nursing

immunosuppression tracheitis follow up vocal cords rituximab non hodgkin s lymphoma lymphoma follicular herpes simplex

Herpetic tracheitis in association with rituximab therapy (2016)

Abstract A 58-year old lady under active follow-up with the respiratory services at our institution for bronchiectasis secondary to hypogammaglobulinaemia presented with hoarseness and haemoptysis. She was also receiving rituximab maintenance therapy for follicular lymphoma. Bronchoscopy demonstrated vesicular lesions on her vocal cords and trachea, confirmed as herpes simplex virus (HSV) on cytological analysis of brushings. She responded well to intravenous valacyclovir. Rituximab is increasingly utilised in the treatment of haematological and auto-immune disorders. This case highlights the potential of this drug to potentiate susceptibility to infection in an already immunocompromised individual.
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Full list of authors on original publication

Desmond M Murphy, Julie McCarthy, Barry J Plant, Lorraine Thong

Experts in our system

Desmond M. Murphy
University College Cork
Total Publications: 30
Barry J Plant
University College Cork
Total Publications: 45