Type

Journal Article

Authors

Michael J. Owen
Gary Donohoe
Michael C. O’Donovan
Aiden Corvin
Michael Gill
Guillén Fernández
Valentina Moskvina
Andrea Da Costa
Martine Hoogman
Derek Morris
and 7 others

Subjects

Psychiatry

Topics
schizophrenia single nucleotide polymorphisms genome wide association studies major histocompatibility complex brain follow up psychology case control

The Role of the Major Histocompatibility Complex Region in Cognition and Brain Structure: A Schizophrenia GWAS Follow-Up (2013)

Abstract Objective The authors investigated the effects of recently identified genome-wide significant schizophrenia genetic risk variants on cognition and brain structure. Method A panel of six single-nucleotide polymorphisms (SNPs) was selected to represent genome-wide significant loci from three recent genome-wide association studies (GWAS) for schizophrenia and was tested for association with cognitive measures in 346 patients with schizophrenia and 2,342 healthy comparison subjects. Nominally significant results were evaluated for replication in an independent case-control sample. For SNPs showing evidence of association with cognition, associations with brain structural volumes were investigated in a large independent healthy comparison sample. Results Five of the six SNPs showed no significant association with any cognitive measure. One marker in the major histocompatibility complex (MHC) region, rs6904071, showed independent, replicated evidence of association with delayed episodic memory and was significant when both samples were combined. In the combined sample of up to 3,100 individuals, this SNP was associated with widespread effects across cognitive domains, although these additional associations were no longer significant after adjusting for delayed episodic memory. In the large independent structural imaging sample, the same SNP was also associated with decreased hippocampal volume. Conclusions The authors identified a SNP in the MHC region that was associated with cognitive performance in patients with schizophrenia and healthy comparison subjects. This SNP, rs6904071, showed a replicated association with episodic memory and hippocampal volume. These findings implicate the MHC region in hippocampal structure and functioning, consistent with the role of MHC proteins in synaptic development and function. Follow-up of these results has the potential to provide insights into the pathophysiology of schizophrenia and cognition.
Collections Ireland -> National College of Ireland -> National College of Ireland -> Subject = B Philosophy. Psychology. Religion
Ireland -> National College of Ireland -> Status = Published
Ireland -> National College of Ireland -> Subject = B Philosophy. Psychology. Religion
Ireland -> National College of Ireland -> National College of Ireland -> Type = Article
Ireland -> National College of Ireland -> National College of Ireland -> Subject = B Philosophy. Psychology. Religion: Psychology
Ireland -> National College of Ireland -> Type = Article
Ireland -> National College of Ireland -> Subject = B Philosophy. Psychology. Religion: Psychology
Ireland -> National College of Ireland -> National College of Ireland -> Status = Published

Full list of authors on original publication

Michael J. Owen, Gary Donohoe, Michael C. O’Donovan, Aiden Corvin, Michael Gill, Guillén Fernández, Valentina Moskvina, Andrea Da Costa, Martine Hoogman, Derek Morris and 7 others

Experts in our system

1
Michael J. Owen
Trinity College Dublin
Total Publications: 20
 
2
Gary Donohoe
Trinity College Dublin
Total Publications: 143
 
3
Aiden Corvin
Trinity College Dublin
Total Publications: 199
 
4
Michael Gill
Trinity College Dublin
Total Publications: 273
 
5
Derek Morris
Trinity College Dublin
Total Publications: 156