Type

Journal Article

Authors

Aiden Corvin
Michael Gill
Derek Morris
K. C. Murphy
J. L. Waddington
F. A. O'Neill
E. O'Callaghan
C. McDonald
T. G. Dinan
Ciara Fahey
and 4 others

Subjects

Psychiatry

Topics
novel the genome wide association schizophrenia bipolar disorder cognition psychology psychotic symptoms cognitive

Mood congruent psychotic symptoms and specific cognitive deficits in carriers of the novel schizophrenia risk variant at MIR-137 (2013)

Abstract Objective The Schizophrenia Psychiatric Genome-wide Association (GWAS) Consortium recently reported on five novel schizophrenia susceptibility loci. The most significant finding mapped to a micro-RNA, MIR-137, which may be involved in regulating the function of other schizophrenia and bipolar disorder susceptibility genes. Method We genotyped 821 patients with confirmed DSM-IV diagnoses of schizophrenia, bipolar affective disorder I and schizoaffective disorder for the risk SNP (rs1625579) and investigated the clinical profiles of risk allele carriers using a within-case design. We also assessed neurocognitive performance in a subset of cases (n = 399) and controls (n = 171). Results Carriers of the risk allele had lower scores for an OPCRIT-derived positive symptom factor (p = 0.04) and lower scores on a lifetime measure of psychosis incongruity (p = 0.017). Risk allele carriers also had more cognitive deficits involving episodic memory and attentional control. Conclusion This is the first evidence that the MIR-137 risk variant may be associated with a specific subgroup of psychosis patients. Although the effect of this single SNP was not clinically relevant, investigation of the impact of carrying multiple risk SNPs in the MIR-137 regulatory network on diagnosis and illness profile may be warranted. Highlights ► We investigated the clinical symptom profiles of carriers of the schizophrenia mir137 risk allele. ► The sample included 821 patients with schizophrenia, schizoaffective disorder and bipolar I disorder. ► Risk allele carriers had lower scores for positive symptoms and less psychosis incongruity. ► On neurocognitive testing in a subset, there were more cognitive deficits in risk allele carriers.
Collections Ireland -> National College Ireland -> Status = Published
Ireland -> National College Ireland -> Subject = B Philosophy. Psychology. Religion
Ireland -> National College of Ireland -> Type = Article
Ireland -> National College Ireland -> Subject = B Philosophy. Psychology. Religion: Psychology
Ireland -> National College of Ireland -> Status = Published
Ireland -> National College of Ireland -> Subject = B Philosophy. Psychology. Religion
Ireland -> National College Ireland -> Subject = B Philosophy. Psychology. Religion: Psychology: Cognition
Ireland -> National College of Ireland -> Subject = B Philosophy. Psychology. Religion: Psychology
Ireland -> National College Ireland -> Type = Article
Ireland -> National College of Ireland -> Subject = B Philosophy. Psychology. Religion: Psychology: Cognition

Full list of authors on original publication

Aiden Corvin, Michael Gill, Derek Morris, K. C. Murphy, J. L. Waddington, F. A. O'Neill, E. O'Callaghan, C. McDonald, T. G. Dinan, Ciara Fahey and 4 others

Experts in our system

1
Aiden Corvin
Trinity College Dublin
Total Publications: 190
 
2
Michael Gill
Trinity College Dublin
Total Publications: 260
 
3
Derek Morris
Trinity College Dublin
Total Publications: 150
 
4
Kathy Murphy
National University of Ireland Galway
Total Publications: 27
 
5
John L Waddington
Royal College of Surgeons in Ireland
Total Publications: 157
 
6
Eadbhard O'Callaghan
University College Dublin
Total Publications: 37
 
7
Colm McDonald
National University of Ireland Galway
Total Publications: 43
 
8
Ciara Fahey
Trinity College Dublin
Total Publications: 30