Type

Journal Article

Authors

Aiden Corvin
Michael Gill
April Hargreaves
Derek Morris
Emma Jane Rose
Gary Donohoe

Subjects

Psychiatry

Topics
cognition schizophrenia and disorders follow up brain function genetic loci brain psychology genome wide association studies

S20-02 - Follow up of schizophrenia gwas based on cognitive performance, high density eeg, and structural brain imaging (2011)

Abstract The advent of genome wide association studies have resulted in the identification of a number of novel genetic loci for schizophrenia and related disorders. Understanding the functional impact of these variants on brain structure and function is crucial to understand their role in disease pathology. We presents data based on our genetic and neuropsychological assessment of almost 700 patients and healthy participants for a number of these variants and replication of our findings in independent samples of almost 1500 cases and controls. Specifically, we will use this data to suggest that the risk associated with some genetics variants (e.g. NOS1) is being mediated by an influence on variation in intelligence and other cognitive phenotypes, while other risk variants (e.g. ZNF804A) delineate illness subtypes in which cognitive deficits are a less prominent feature.
Collections Ireland -> National College of Ireland -> Subject = B Philosophy. Psychology. Religion
Ireland -> National College of Ireland -> Type = Article
Ireland -> National College of Ireland -> Subject = B Philosophy. Psychology. Religion: Psychology
Ireland -> National College of Ireland -> Status = Published
Ireland -> National College of Ireland -> Subject = B Philosophy. Psychology. Religion: Psychology: Cognition

Full list of authors on original publication

Aiden Corvin, Michael Gill, April Hargreaves, Derek Morris, Emma Jane Rose, Gary Donohoe

Experts in our system

1
Aiden Corvin
Trinity College Dublin
Total Publications: 190
 
2
Michael Gill
Trinity College Dublin
Total Publications: 260
 
3
April Hargreaves
Trinity College Dublin
Total Publications: 27
 
4
Derek Morris
Trinity College Dublin
Total Publications: 150
 
5
Emma Jane Rose
Trinity College Dublin
Total Publications: 19
 
6
Gary Donohoe
Trinity College Dublin
Total Publications: 130