Type

Other / n/a

Authors

Cathal Kearney
Fergal O'Brien
Conor T Buckley
Valeria Nicolosi
Chris Hobbs
Darina A Gilroy

Subjects

Engineering

Topics
iron oxide anatomy dynamic loading bioreactors tissue engineering scaffolds material properties scaffolds cell viability

Development of magnetically active scaffolds as intrinsically-deformable bioreactors (2017)

Abstract Mesenchymal stem cell behavior can be regulated through mechanical signaling, either by dynamic loading or through biomaterial properties. We developed intrinsically responsive tissue engineering scaffolds that can dynamically load cells. Porous collagen- and alginate-based scaffolds were functionalized with iron oxide to produce magnetically active scaffolds. Reversible deformations in response to magnetic stimulation of up to 50% were recorded by tuning the material properties. Cells could attach to these scaffolds and magnetically induced compressive deformation did not adversely affect viability or cause cell release. This platform should have broad application in the mechanical stimulation of cells for tissue engineering applications.
Collections Ireland -> Royal College of Surgeons in Ireland -> Anatomy Articles
Ireland -> Royal College of Surgeons in Ireland -> Department of Anatomy

Full list of authors on original publication

Cathal Kearney, Fergal O'Brien, Conor T Buckley, Valeria Nicolosi, Chris Hobbs, Darina A Gilroy

Experts in our system

1
Cathal J Kearney
Royal College of Surgeons in Ireland
Total Publications: 14
 
2
Fergal J O'Brien
Royal College of Surgeons in Ireland
Total Publications: 268
 
3
Conor T Buckley
Trinity College Dublin
Total Publications: 91