Type

Other / n/a

Authors

Arnold DK Hill
Ronán M Conroy
Michael Quirke
Firas Ayoub

Subjects

Medicine & Nursing

Topics
systematic review surgical site infection surgery chlorhexidine alcohol povidone iodine medicine and health sciences meta analysis randomized controlled trials

Chlorhexidine-alcohol versus povidone-iodine for pre-operative skin preparation: A systematic review and meta-analysis. (2015)

Abstract Background: Surgical site infection (SSI) is a dreaded postoperative complication. Although preoperative skin cleansing in order to prevent surgical site infection (SSI) is standard surgical practice, there is clinical equipoise concerning whether povidone iodine (PI) or chlorhexidine alcohol (CHA) is the antiseptic agent of choice.Objectives: To determine whether CHA or PI is the preferred preoperative skin preparation for reducing SSI in clean, clean-contaminated and contaminated surgery.Search methods: PubMed, Embase, and gray literature sources were searched for randomized controlled trials (RCTs) comparing both CHA and PI between 1980 and 2014. Comparative RCTs of preoperative CHA versus PI studying SSI in clean, clean-contaminated and contaminated surgery were included. Risk of bias was assessed using Cochrane risk of bias.Main result: We identified six eligible studies with an overall 2484 participants. The overall rate of SSI was 6.8% in the CHA group versus 11.0% in the PI group (P < 0.0002). CHA was superior to PI in the prevention of SSI with a pooled RR of 0.62 (95% CI, 0.48–0.81).Conclusions: Preoperative surgical skin preparation with CHA is more effective than PI in preventing SSI across clean and clean-contaminated surgery. Further studies should evaluate the effectiveness of CHA versus PI in contaminated surgery.
Collections Ireland -> Royal College of Surgeons in Ireland -> Department of Surgery
Ireland -> Royal College of Surgeons in Ireland -> Department of Epidemiology and Public Health Medicine
Ireland -> Royal College of Surgeons in Ireland -> Epidemiology and Public Health Medicine Articles
Ireland -> Royal College of Surgeons in Ireland -> Division of Population Health Sciences
Ireland -> Royal College of Surgeons in Ireland -> Surgery Articles

Full list of authors on original publication

Arnold DK Hill, Ronán M Conroy, Michael Quirke, Firas Ayoub

Experts in our system

1
Arnold D K Hill
Royal College of Surgeons in Ireland
Total Publications: 110
 
2
Ronán Conroy
Royal College of Surgeons in Ireland
Total Publications: 150
 
3
Michael Quirke
Royal College of Surgeons in Ireland
Total Publications: 17