Type

Other / n/a

Authors

Gianpiero L Cavalleri
Anna Di Rienzo
Peter Robbins
Hugh Montgomery
Paolo Gasparini
Nobumitsu Kobayashi
Masao Ota
Masayuki Hanaoka
Yunden Droma
Dhana R Aryal
and 4 others

Subjects

Environment

Topics
tibetan life sciences nepalese gene flow subpopulations sherpa principal component analysis admixture nepal consanguinity

Genetic structure in the Sherpa and neighboring Nepalese populations. (2017)

Abstract BACKGROUND: We set out to describe the fine-scale population structure across the Eastern region of Nepal. To date there is relatively little known about the genetic structure of the Sherpa residing in Nepal and their genetic relationship with the Nepalese. We assembled dense genotype data from a total of 1245 individuals representing Nepal and a variety of different populations resident across the greater Himalayan region including Tibet, China, India, Pakistan, Kazakhstan, Uzbekistan, Tajikistan and Kirghizstan. We performed analysis of principal components, admixture and homozygosity.RESULTS: We identified clear substructure across populations resident in the Himalayan arc, with genetic structure broadly mirroring geographical features of the region. Ethnic subgroups within Nepal show distinct genetic structure, on both admixture and principal component analysis. We detected differential proportions of ancestry from northern Himalayan populations across Nepalese subgroups, with the Nepalese Rai, Magar and Tamang carrying the greatest proportions of Tibetan ancestry.CONCLUSIONS: We show that populations dwelling on the Himalayan plateau have had a clear impact on the Northern Indian gene pool. We illustrate how the Sherpa are a remarkably isolated population, with little gene flow from surrounding Nepalese populations.
Collections Ireland -> Royal College of Surgeons in Ireland -> Department of Molecular and Cellular Therapeutics
Ireland -> Royal College of Surgeons in Ireland -> Molecular and Cellular Therapeutics Articles

Full list of authors on original publication

Gianpiero L Cavalleri, Anna Di Rienzo, Peter Robbins, Hugh Montgomery, Paolo Gasparini, Nobumitsu Kobayashi, Masao Ota, Masayuki Hanaoka, Yunden Droma, Dhana R Aryal and 4 others

Experts in our system

1
Gianpiero L Cavalleri
Royal College of Surgeons in Ireland
Total Publications: 35
 
2
Peter A Robbins
Royal College of Surgeons in Ireland
Total Publications: 6