Type

Journal Article

Authors

R. Paul Ross
Colin Hill
Paul D. Cotter
Mary C Rea
Des Field
Harsh Mathur

Subjects

Veterinary

Topics
antimicrobial bacteriocins synergy antibiotic resistance antimicrobials antimicrobial resistance food borne pathogens adverse effects medical pathogens bacteriocin stressors food combinations

Bacteriocin-Antimicrobial Synergy: A Medical and Food Perspective (2017)

Abstract The continuing emergence of multi-drug resistant pathogens has sparked an interest in seeking alternative therapeutic options. Antimicrobial combinatorial therapy is one such avenue. A number of studies have been conducted, involving combinations of bacteriocins with other antimicrobials, to circumvent the development of antimicrobial resistance and/or increase antimicrobial potency. Such bacteriocin-antimicrobial combinations could have tremendous value, in terms of reducing the likelihood of resistance development due to the involvement of two distinct mechanisms of antimicrobial action. Furthermore, antimicrobial synergistic interactions may also have potential financial implications in terms of decreasing the costs of treatment by reducing the concentration of an expensive antimicrobial and utilizing it in combination with an inexpensive one. In addition, combinatorial therapies with bacteriocins can broaden antimicrobial spectra and/or result in a reduction in the concentration of an antibiotic required for effective treatments to the extent that potentially toxic or adverse side effects can be reduced or eliminated. Here, we review studies in which bacteriocins were found to be effective in combination with other antimicrobials, with a view to targeting clinical and/or food-borne pathogens. Furthermore, we discuss some of the bottlenecks which are currently hindering the development of bacteriocins as viable therapeutic options, as well as addressing the need to exercise caution when attempting to predict clinical outcomes of bacteriocin-antimicrobial combinations.
Collections Ireland -> Teagasc -> Food Biosciences

Full list of authors on original publication

R. Paul Ross, Colin Hill, Paul D. Cotter, Mary C Rea, Des Field, Harsh Mathur

Experts in our system

1
R Paul Ross
Teagasc
Total Publications: 441
 
2
Colin Hill
University College Cork
Total Publications: 351
 
3
Paul D. Cotter
Teagasc
Total Publications: 253
 
4
Mary C. Rea
Teagasc
Total Publications: 68
 
5
Des Field
Teagasc
Total Publications: 30
 
6
Harsh Mathur
University College Cork
Total Publications: 9