Type

Journal Article

Authors

Derek Williams Morris
Michael Gill
Aiden Corvin

Subjects

Psychiatry

Topics
alpha subunit supports genome wide association support calcium bipolar disorder collaborative psychiatry

Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. (2008)

Abstract To identify susceptibility loci for bipolar disorder, we tested 1.8 million variants in 4,387 cases and 6,209 controls and identified a region of strong association (rs10994336, P = 9.1 10-9) in ANK3 (ankyrin G). We also found further support for the previously reported CACNA1C (alpha 1C subunit of the L-type voltage-gated calcium channel; combined P = 7.0 10-8, rs1006737). Our results suggest that ion channelopathies may be involved in the pathogenesis of bipolar disorder.
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Full list of authors on original publication

Derek Williams Morris, Michael Gill, Aiden Corvin

Experts in our system

1
Derek Morris
Trinity College Dublin
Total Publications: 150
 
2
Michael Gill
Trinity College Dublin
Total Publications: 260
 
3
Aiden Corvin
Trinity College Dublin
Total Publications: 190