Type

Journal Article

Authors

Michael Fitzgerald
Ziarih Hawi
Louise Gallagher
Ricardo Segurado
Michael Gill

Subjects

Psychiatry

Topics
neuroscience psychiatry attention deficit hyperactivity disorder adhd adolescent psychiatry general hospital psychiatry consultation liaison psychiatry add adhd alleles liaison psychiatry child and adolescent psychiatry adhd neuropsychiatry disorder adhd neurodevelopmental psychiatry child psychiatry community psychiatry

Preferential Transmission of Paternal Alleles at Risk Genes in Attention Deficit/Hyperactivity Disorder (2005)

Abstract (239) PMID: 16380908 ABSTRACT: Family, twin, and adoption studies have demonstrated a significant genetic contribution to the etiology of attention-deficit/hyperactivity disorder (ADHD). Pharmacological, neuroimaging, and animal-model findings suggest imbalances in monoaminergic (dopaminergic, serotonergic, and noradrenergic) neurotransmission in ADHD. We have examined monoaminergic candidate genes for possible genetic association with ADHD in the Irish population, focusing particularly on genes of the dopaminergic and serotonergic systems. We have observed that several of these genes are associated with ADHD, including DAT1, DBH, DRD4, DRD5, and 5HT1B. Here, we present what appears to be a systematic overtransmission of paternal alleles at candidate genes associated with ADHD. For the nine genes included in the analysis, the overall odds ratio for paternal transmission was 2, compared with 1.3 for maternal transmission (paternal vs. maternal chi 2=9.6; P=.0019). Transmission to females, from either parent, was significantly stronger than to males. Possible reasons for this preferential transmission include imprinting and ascertainment bias, although results of further analyses show that the latter is unlikely.
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Full list of authors on original publication

Michael Fitzgerald, Ziarih Hawi, Louise Gallagher, Ricardo Segurado, Michael Gill

Experts in our system

1
Michael Fitzgerald
Trinity College Dublin
Total Publications: 90
 
2
Ziarih Hawi
Trinity College Dublin
Total Publications: 28
 
3
Louise Gallagher
Trinity College Dublin
Total Publications: 55
 
4
Ricardo Segurado
University College Dublin
Total Publications: 58
 
5
Michael Gill
Trinity College Dublin
Total Publications: 260