Journal Article


Michael Fitzgerald
Ziarih Hawi
Michael Gill



neurodevelopmental psychiatry child psychiatry community psychiatry general hospital psychiatry psychiatry consultation liaison psychiatry add adhd liaison psychiatry child and adolescent psychiatry adhd neuropsychiatry disorder adhd neuroscience 5 ht1b transmission disequilibrium test tdt haplotype based haplotype relative risk hhrr attention deficit hyperactivity disorder adhd adolescent psychiatry trainees in psychiatry 5 htr2a 5 ht1b receptor gene 5 htr1b serotonergic responsivity 5 ht

Serotonergic System and Attention Deficit Hyperactivity Disorder (ADHD): a potential susceptibility locus at the 5-HT1B receptor gene in 270 Trios from a multi-center sample (2002)

Abstract PMID: 12192616 ABSTRACT:Attention deficit hyperactivity disorder (ADHD) is a highly heritable and heterogeneous disorder, which usually becomes apparent during the first few years of childhood. Imbalance in dopamine neurotransmission has been suggested as a factor predisposing to ADHD. However, evidence has suggested an interaction between dopamine and serotonin systems in the pathophysiology of the disorder. Studies using selective agonists of the different 5-HT receptors microinjected into selected brain structures have shown a positive modulating effect on the functional activities of the mesotelencephalic dopaminergic system. This suggests that some of the genetic predisposition to ADHD might be due to DNA variation at serotonin system genes. In this study, we investigated polymorphisms in HTR(1B) and HTR(2A) (which encode the serotonin receptors 5-HT(1B) and 5-HT(2A) respectively) in a European ADHD sample. Using haplotype based haplotype relative risk (HHRR) and transmission disequilibrium test (TDT) analyses, we observed significant preferential transmission of the allele 861G of the HTR(1B) in the total sample (for HHRR; chi(2) = 7.4, P = 0.0065 and TDT; (chi(2) = 6.4, P = 0.014). Analysis of HTR(2A) failed to reveal evidence of association or linkage between the His452Tyr polymorphism and ADHD in the total sample. However, a significantly increased transmission of the allele 452His was observed in the Irish sample alone (chi(2) = 4.9, P = 0.026). These preliminary data suggest an important role for the serotonin system in the development of ADHD. Further studies, preferentially including different ethnic groups are required to substantiate these findings.
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Full list of authors on original publication

Michael Fitzgerald, Ziarih Hawi, Michael Gill

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Michael Fitzgerald
Trinity College Dublin
Total Publications: 90
Ziarih Hawi
Trinity College Dublin
Total Publications: 28
Michael Gill
Trinity College Dublin
Total Publications: 260