Type

Working Paper

Authors

Dermot Kelleher
James Meaney
Danuta Lisiecka
Andrew Fagan
Thomas Frodl
Angela Carballedo

Subjects

Psychiatry

Topics
psychiatry genes society major depressive disorder mdd neuroimaging mental disorders neuroscience high resolution family history

Microstructural Correlates of Resilience against Major Depressive Disorder: Epigenetic Mechanisms? (2010)

Abstract Mental disorders are a major cause of long-term disability and are a direct cause of mortality, with approximately 800.000 individuals dying from suicide every year worldwide ? a high proportion of them related to major depressive disorder (MDD)1. Healthy relatives of patients with major depressive disorder (MDD) are at risk to develop the disease. This higher vulnerability is associated with structural2-4 and functional brain changes5. However, we found using high angular resolution diffusion imaging (HARDI) with 61 diffusion directions that neuron tracts between frontal cortices and limbic as well as temporal and parietal brain regions are characterized by better diffusion coefficients in unaffected relatives (UHR), who managed to stay healthy, compared to healthy volunteers without any family history for a psychiatric disease (HC). Moreover, those UHR with stronger fibre connections better managed incidences of adversity in early life without later developing depression, while in HC axonal connections were found to be decreased when they had early-life adversity. Altogether these findings indicate the presence of stronger neural fibre connections in UHR, which seem to be associated with resilience against environmental stressors, which we suggest occur through epigenetic mechanisms.
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Full list of authors on original publication

Dermot Kelleher, James Meaney, Danuta Lisiecka, Andrew Fagan, Thomas Frodl, Angela Carballedo

Experts in our system

1
Dermot Kelleher
Trinity College Dublin
Total Publications: 144
 
2
James Meaney
Trinity College Dublin
Total Publications: 28
 
3
Danuta Lisiecka
Trinity College Dublin
Total Publications: 8
 
4
Andrew John Fagan
Trinity College Dublin
Total Publications: 72
 
5
Thomas Frodl
Trinity College Dublin
Total Publications: 58
 
6
Angela Carballedo
Trinity College Dublin
Total Publications: 23