Type

Journal Article

Authors

Michael Gill
Gianfranco Spalletta
Derek Morris
Paola Bossù
Thomas Frodl
Carlo Caltagirone
Gary (James) Donohoe
Sergio Bernardini
Emma Rose
Fulvia Adriano
and 2 others

Subjects

Psychiatry

Topics
cognition amygdala kruppel like transcription factors physiology polymorphism single nucleotide schizophrenia alleles psychiatry schizophrenic psychology znf804a protein human prefrontal cortex frontal cortex brain voxel based morphometry adult znf804a magnetic resonance imaging humans genotype female risk assessment hippocampus genetics demography memory function male patients image processing computer assisted heterozygote memory pathology data interpretation statistical

ZNF804A risk allele is associated with relatively intact gray matter volume in patients with schizophrenia (2010)

Abstract ZNF804A rs1344706 is the first genetic risk variant to achieve genome wide significance for psychosis. Following earlier evidence that patients carrying the ZNF804A risk allele had relatively spared memory function compared to patient non-carriers, we investigated whether ZNF804A was also associated with variation in brain volume. In a sample of 70 patients and 38 healthy participants we used voxel based morphometry to compare homozygous (AA) carriers of the ZNF804A risk allele to heterozygous and homozygous (AC/CC) non-carriers for both whole brain volume and specific regions implicated in earlier ZNF804A studies ?the dorsolateral pre-frontal cortex, the hippocampus, and the amygdala. For patients, but not for controls, we found that homozygous `AA? risk carriers had relatively larger gray matter volumes than heterozygous/homozygous non-carriers (AC/CC), particularly for hippocampal volumes. These data are consistent with our earlier behavioral data and suggest that ZNF804A is delineating a schizophrenia subtype characterized by relatively intact brain volume. Establishing if this represents a discrete molecular pathogenesis with consequences for nosology and treatment will be an important next step in understanding ZNF084A's role in illness risk.
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Full list of authors on original publication

Michael Gill, Gianfranco Spalletta, Derek Morris, Paola Bossù, Thomas Frodl, Carlo Caltagirone, Gary (James) Donohoe, Sergio Bernardini, Emma Rose, Fulvia Adriano and 2 others

Experts in our system

1
Michael Gill
Trinity College Dublin
Total Publications: 260
 
2
Gianfranco Spalletta
Trinity College Dublin
Total Publications: 5
 
3
Derek Morris
Trinity College Dublin
Total Publications: 150
 
4
Paola Bossù
Trinity College Dublin
Total Publications: 4
 
5
Thomas Frodl
Trinity College Dublin
Total Publications: 58
 
6
Carlo Caltagirone
Trinity College Dublin
Total Publications: 4
 
7
Gary Donohoe
Trinity College Dublin
Total Publications: 130
 
8
Emma Jane Rose
Trinity College Dublin
Total Publications: 19