Type

Journal Article

Authors

Mairead Mary Bartley
Colby Tanner
Harald Hampel
Desmond O'Neill
Daniel Ronan Collins
Arun Lawrence Warren Bokde
Tara Leah Coughlan

Subjects

Psychiatry

Topics
temporal lobe prefrontal cortex alzheimer s disease ad white matter mild cognitive impairment gerontology neuroscience corpus callosum

Multiple Indices of Diffusion Identifies White Matter Damage in Mild Cognitive Impairment and Alzheimer s Disease (2011)

Abstract The study of multiple indices of diffusion, including axial (DA), radial (DR) and mean diffusion (MD), as well as fractional anisotropy (FA), enables WM damage in Alzheimer's disease (AD) to be assessed in detail. Here, tract-based spatial statistics (TBSS) were performed on scans of 40 healthy elders, 19 non-amnestic MCI (MCIna) subjects, 14 amnestic MCI (MCIa) subjects and 9 AD patients. Significantly higher DA was found in MCIna subjects compared to healthy elders in the right posterior cingulum/precuneus. Significantly higher DA was also found in MCIa subjects compared to healthy elders in the left prefrontal cortex, particularly in the forceps minor and uncinate fasciculus. In the MCIa versus MCIna comparison, significantly higher DA was found in large areas of the left prefrontal cortex. For AD patients, the overlap of FA and DR changes and the overlap of FA and MD changes were seen in temporal, parietal and frontal lobes, as well as the corpus callosum and fornix. Analysis of differences between the AD versus MCIna, and AD versus MCIa contrasts, highlighted regions that are increasingly compromised in more severe disease stages. Microstructural damage independent of gross tissue loss was widespread in later disease stages. Our findings suggest a scheme where WM damage begins in the core memory network of the temporal lobe, cingulum and prefrontal regions, and spreads beyond these regions in later stages. DA and MD indices were most sensitive at detecting early changes in MCIa.
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Full list of authors on original publication

Mairead Mary Bartley, Colby Tanner, Harald Hampel, Desmond O'Neill, Daniel Ronan Collins, Arun Lawrence Warren Bokde, Tara Leah Coughlan

Experts in our system

1
Harald Hampel
Trinity College Dublin
Total Publications: 35
 
2
Desmond O'Neill
Trinity College Dublin
Total Publications: 140
 
3
D R Collins
Trinity College Dublin
Total Publications: 27
 
4
Arun L W Bokde
Trinity College Dublin
Total Publications: 144
 
5
Tara Coughlan
Trinity College Dublin
Total Publications: 35