Type

Journal Article

Authors

Derek Morris
Ian H Robertson
Sinead Kelly
Jane Mc Grath
John Philip O'Doherty
Arun Lawrence Warren Bokde
Hugh Patrick Garavan
Ciara Fahey
Emma Rose
Fiona Newell
and 4 others

Subjects

Psychiatry

Topics
voxel based morphometry prefrontal cortex spatial working memory cognitive function schizophrenia nitric oxide neuroscience parietal lobe

The NOS1 variant rs6490121 is associated with variation in prefrontal function and gray matter density in healthy individuals (2012)

Abstract A common polymorphism within the nitric oxide sythanse-1 (NOS1) gene (rs6490121), initially identified as risk variant for schizophrenia, has been associated with variation in working memory and IQ. Here we investigated how this variation might be mediated at the level of brain structure and function. In healthy individuals (N = 157), voxel based morphometry was used to compare gray matter (GM) volume between homozygous and heterozygous carriers of the `G? allele (i.e. the allele associated with impaired cognition and schizophrenia risk) and homozygous carriers of the non-risk `A? allele. Functional brain imaging data were also acquired from 48 participants during performance of a spatial working memory (SWM) task, and analysed to determine any effect of NOS1 risk status. An a priori region-of-interest analysis identified a significant reduction in ventromedial prefrontal GM volume in `G? allele carriers. Risk carriers also exhibited altered patterns of activation in the prefrontal cortex, caudate, and superior parietal lobe, which were characteristic of abnormal increases in activation in frontoparietal working memory networks and a failure to disengage regions of the default mode network. These functional changes suggest a NOS1-mediated processing inefficiency that may contribute to cognitive dysfunction in schizophrenia. While the mechanisms by which NOS1 may influence brain structure and/or function have not yet been well delineated, these data provide further evidence for a role of NOS1 in risk for schizophrenia via an impact upon cognitive function.
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Full list of authors on original publication

Derek Morris, Ian H Robertson, Sinead Kelly, Jane Mc Grath, John Philip O'Doherty, Arun Lawrence Warren Bokde, Hugh Patrick Garavan, Ciara Fahey, Emma Rose, Fiona Newell and 4 others

Experts in our system

1
Derek Morris
Trinity College Dublin
Total Publications: 150
 
2
Ian H Robertson
Trinity College Dublin
Total Publications: 142
 
3
Sinead Kelly
Trinity College Dublin
Total Publications: 16
 
4
John P O'Doherty
Trinity College Dublin
Total Publications: 19
 
5
Arun L W Bokde
Trinity College Dublin
Total Publications: 76
 
6
Hugh Garavan
Trinity College Dublin
Total Publications: 160
 
7
Ciara Fahey
Trinity College Dublin
Total Publications: 30
 
8
Emma Jane Rose
Trinity College Dublin
Total Publications: 19
 
9
Fiona N. Newell
Trinity College Dublin
Total Publications: 54