Journal Article


Clyde Francks
Simon E Fisher
Bernard Mazoyer
David C Glahn
Paul M Thompson
Barbara Franke
JingJing Zhao
Je-Yeon Yun
Xiufeng Xu
Jian Xu
and 151 others



sample size brain people human meta analysis globus pallidus age basal ganglia

Human subcortical brain asymmetries in 15,847 people worldwide reveal effects of age and sex (2016)

Abstract The two hemispheres of the human brain differ functionally and structurally. Despite over a century of research, the extent to which brain asymmetry is influenced by sex, handedness, age, and genetic factors is still controversial. Here we present the largest ever analysis of subcortical brain asymmetries, in a harmonized multi-site study using meta-analysis methods. Volumetric asymmetry of seven subcortical structures was assessed in 15,847 MRI scans from 52 datasets worldwide. There were sex differences in the asymmetry of the globus pallidus and putamen. Heritability estimates, derived from 1170 subjects belonging to 71 extended pedigrees, revealed that additive genetic factors influenced the asymmetry of these two structures and that of the hippocampus and thalamus. Handedness had no detectable effect on subcortical asymmetries, even in this unprecedented sample size, but the asymmetry of the putamen varied with age. Genetic drivers of asymmetry in the hippocampus, thalamus and basal ganglia may affect variability in human cognition, including susceptibility to psychiatric disorders.
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Full list of authors on original publication

Clyde Francks, Simon E Fisher, Bernard Mazoyer, David C Glahn, Paul M Thompson, Barbara Franke, JingJing Zhao, Je-Yeon Yun, Xiufeng Xu, Jian Xu and 151 others

Experts in our system

Paul M Thompson
National University of Ireland Galway
Total Publications: 17
Barbara Franke
Trinity College Dublin
Total Publications: 12